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Details on Person UniProt:O15541 RNF113A
| Class:Id | ReferenceGeneProduct:67894 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-343 added on Fri February 6 2015;initiator methionine:1 for 67894 removed on Fri Nov 03 2023;initiator methionine: for 67894 added on Fri Nov 03 2023;initiator methionine: for 67894 removed on Fri Aug 15 2025;initiator methionine:1 for 67894 added on Fri Aug 15 2025 |
| _displayName | UniProt:O15541 RNF113A |
| _timestamp | 2025-08-15 21:33:13 |
| chain | initiator methionine:1 chain:2-343 |
| checksum | F76E28037A6FF78B |
| comment | FUNCTION Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106, PubMed:29361316). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of pre-catalytic and catalytic spliceosome complexes (PubMed:22365833, PubMed:29360106, PubMed:29361316). Interacts (via N-terminus) with the spliceosome subunit SNRNP200/BRR2 (PubMed:29144457). Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with SCNM1 and CRIPT (PubMed:33509932).INTERACTION Colocalizes with ASCC2 in nuclear foci after DNA damage by alkylating agents. In the absence of DNA damage, colocalizes with the spliceosome components SNRNP200/BRR2 and PRPF8 in nuclear speckles.TISSUE SPECIFICITY Ubiquitous.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: E3 ubiquitin-protein ligase RNF113A ecNumber evidence="6 7"2.3.2.27 alternativeName: fullName evidence="13"Cwc24 homolog alternativeName: RING finger protein 113A alternativeName: fullName evidence="12"Zinc finger protein 183 |
| geneName | RNF113A RNF113 ZNF183 |
| identifier | O15541 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation DNA damage DNA repair Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Spliceosome Transferase Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RNF113A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993257] ENSEMBL:ENSG00000125352 RNF113A [Homo sapiens] |
| secondaryIdentifier | R113A_HUMAN B2RBR7 |
| sequenceLength | 343 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9769563] RNF113A [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O15541 RNF113A (67894)
