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Details on Person According to the classical model, phosphorylated Signal tran...
| Class:Id | Summation:6789339 |
|---|---|
| _displayName | According to the classical model, phosphorylated Signal tran... |
| _timestamp | 2015-09-10 16:02:34 |
| created | [InstanceEdit:6789329] Jupe, Steve, 2015-07-30 |
| literatureReference | [LiteratureReference:873866] Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions [LiteratureReference:6786069] Requirements for interleukin-4-induced gene expression and functional characterization of Stat6 [LiteratureReference:1112553] Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway [LiteratureReference:6784756] STATs dimerize in the absence of phosphorylation [LiteratureReference:6784771] Canonical and non-canonical JAK-STAT signaling [LiteratureReference:6784764] Signal transducers and activators of transcription-from cytokine signalling to cancer biology |
| modified | [InstanceEdit:6797418] Jupe, Steve, 2015-09-10 |
| text | According to the classical model, phosphorylated Signal transducer and activator of transcription (STAT) monomers associate in an active dimer form, which is stabilized by the reciprocal interactions between a phosphorylated tyrosine residue of one and the SH2 domain of the other (Shuai et al. 1994, Mikita et al. 1996). These dimers then translocate to the nucleus (Akira et al. 1994). Recently an increasing number of studies have demonstrated the existence of STAT dimers in unstimulated cell states, and the capability of STATs to exert biological functions independently of phosphorylation (Braunstein et al. 2003, Li et al. 2008, Santos & Costas-Pereira 2011). As phosphorylation of STATs is not unequivocally required for its subsequent translocation to the nucleus, this event is shown as an uncertain process. |
| (summation) | [BlackBoxEvent:6786097] p-Y705-STAT3, p-Y641-STAT6 dimerise [Homo sapiens] |
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No pathways have been reviewed or authored by According to the classical model, phosphorylated Signal tran... (6789339)
