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Details on Person Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)

Class:Id	Reaction:6789126
_displayName	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
_doRelease	TRUE
_timestamp	2020-02-24 17:51:56
authored	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
catalystActivity	[CatalystActivity:6789103] peroxidase activity of MPO:ferriheme [phagocytic vesicle lumen]
compartment	[Compartment:1222282] phagocytic vesicle lumen
created	[InstanceEdit:6789177] Shamovsky, Veronica, 2015-07-29
edited	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
input	[SimpleEntity:1222719] H2O2 [phagocytic vesicle lumen] [SimpleEntity:1470067] H+ [phagocytic vesicle lumen] [SimpleEntity:6788973] Cl- [phagocytic vesicle lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:6803668] Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids [LiteratureReference:6803564] Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention [LiteratureReference:6789156] X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution [LiteratureReference:6789139] Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing [LiteratureReference:6806057] Myeloperoxidase: a front-line defender against phagocytosed microorganisms
modified	[InstanceEdit:6803682] Shamovsky, Veronica, 2015-10-07 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8942045] Shamovsky, Veronica, 2016-10-07 [InstanceEdit:9625557] Shamovsky, Veronica, 2018-10-20 [InstanceEdit:9628189] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9676972] Shamovsky, Veronica, 2020-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
output	[SimpleEntity:6789150] HOCl [phagocytic vesicle lumen] [SimpleEntity:1222475] H2O [phagocytic vesicle lumen]
precedingEvent	[Reaction:6789092] NOX2 generates superoxide anion from oxygen [Homo sapiens] [Reaction:5668605] RAC2:GTP binds NOX2 complex [Homo sapiens]
releaseDate	2018-12-13
reviewed	[InstanceEdit:9628191] N�sse, Oliver, 2018-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8885109] R-HSA-6789126.3
summation	[Summation:6803681] Phagosomal myeloperoxidase (MPO) is an important heme enzyme...
(hasEvent)	[Pathway:8941413] Events associated with phagocytolytic activity of PMN cells [Homo sapiens]
(precedingEvent)	[Reaction:6788974] Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) [Homo sapiens] [Reaction:9625548] Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride [Homo sapiens] [Reaction:9625904] Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine [Homo sapiens]
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No pathways have been reviewed or authored by Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (6789126)