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Details on Person Hydroxyl radical reacts with the base and sugar moiety of DNA

Class:Id	Reaction:6789114
_displayName	Hydroxyl radical reacts with the base and sugar moiety of DNA
_doRelease	TRUE
_timestamp	2018-11-07 00:16:14
authored	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
compartment	[Compartment:21994] phagocytic vesicle
created	[InstanceEdit:6789177] Shamovsky, Veronica, 2015-07-29
edited	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
entityOnOtherCell	[DefinedSet:6788972] 8,5'-cdA, cdG within DNA [cytoplasm] [SimpleEntity:29356] H2O [cytosol] [DefinedSet:6789054] dA, dG within DNA [cytoplasm] [SimpleEntity:5333776] hydroxyl [cytosol]
input	[DefinedSet:6789054] dA, dG within DNA [cytoplasm] [SimpleEntity:5333776] hydroxyl [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6789148] DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone [LiteratureReference:6789157] Mechanisms of free radical-induced damage to DNA
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9625999] Shamovsky, Veronica, 2018-10-24 [InstanceEdit:9628189] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hydroxyl radical reacts with the base and sugar moiety of DNA
output	[DefinedSet:6788972] 8,5'-cdA, cdG within DNA [cytoplasm] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:6789160] Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ [Homo sapiens] [BlackBoxEvent:6789077] Hydrogen peroxide enters the bacterium [Homo sapiens] [Reaction:6789109] Superoxide anion reacts with Fe-S cluster [Homo sapiens]
releaseDate	2018-12-13
reviewed	[InstanceEdit:9628191] Nüsse, Oliver, 2018-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8885123] R-HSA-6789114.2
summation	[Summation:6789032] The hydroxyl radical (•OH) is a highly reactive oxygen speci...
(hasEvent)	[Pathway:1222556] ROS and RNS production in phagocytes [Homo sapiens]
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No pathways have been reviewed or authored by Hydroxyl radical reacts with the base and sugar moiety of DNA (6789114)