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Details on Person NOX2 generates superoxide anion from oxygen

Class:Id	Reaction:6789092
_displayName	NOX2 generates superoxide anion from oxygen
_doRelease	TRUE
_timestamp	2018-11-07 00:17:29
authored	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
catalystActivity	[CatalystActivity:5668645] superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]
compartment	[Compartment:1222282] phagocytic vesicle lumen [Compartment:1222693] phagocytic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:6789177] Shamovsky, Veronica, 2015-07-29
edited	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
input	[SimpleEntity:1222561] O2 [phagocytic vesicle lumen] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:1222561] O2 [phagocytic vesicle lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:1222582] NADPH oxidase: an update [LiteratureReference:8942028] Assembly and activation of the neutrophil NADPH oxidase in granule membranes
modified	[InstanceEdit:6803683] Shamovsky, Veronica, 2015-10-07 [InstanceEdit:6803798] Shamovsky, Veronica, 2015-10-07 [InstanceEdit:6804052] Shamovsky, Veronica, 2015-10-08 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8941410] Shamovsky, Veronica, 2016-09-30 [InstanceEdit:9625028] Shamovsky, Veronica, 2018-10-18 [InstanceEdit:9625557] Shamovsky, Veronica, 2018-10-20 [InstanceEdit:9626218] Shamovsky, Veronica, 2018-10-26 [InstanceEdit:9628189] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOX2 generates superoxide anion from oxygen
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:1222461] O2.- [phagocytic vesicle lumen] [SimpleEntity:1222461] O2.- [phagocytic vesicle lumen]
precedingEvent	[Reaction:5668605] RAC2:GTP binds NOX2 complex [Homo sapiens]
releaseDate	2018-12-13
reviewed	[InstanceEdit:9628191] N�sse, Oliver, 2018-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8911769] R-HSA-6789092.2
summation	[Summation:6789009] Phagocytic cells kill microorganisms by ingesting them into ...
(hasEvent)	[Pathway:1222556] ROS and RNS production in phagocytes [Homo sapiens]
(precedingEvent)	[Reaction:6788975] Superoxide anion dismutates to H2O2 [Homo sapiens] [Reaction:6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) [Homo sapiens] [Reaction:8942052] Superoxide and nitric oxide react to peroxynitrite in the phagosome [Homo sapiens]
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No pathways have been reviewed or authored by NOX2 generates superoxide anion from oxygen (6789092)