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Details on Person PGLYRP1 binds bacterial peptidoglycan

Class:IdReaction:6789072
_displayNamePGLYRP1 binds bacterial peptidoglycan
_doReleaseTRUE
_timestamp2023-05-25 21:54:54
authored[InstanceEdit:6803156] Shamovsky, Veronica, 2015-10-05
compartment[Compartment:1222282] phagocytic vesicle lumen
[Compartment:25409] peptidoglycan-based cell wall
created[InstanceEdit:6789177] Shamovsky, Veronica, 2015-07-29
edited[InstanceEdit:8935852] Shamovsky, Veronica, 2016-08-15
entityOnOtherCell[SimpleEntity:6789198] GlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2 [peptidoglycan-based cell wall]
input[Complex:6789200] PGLYRP1 dimer [phagocytic vesicle lumen] [Homo sapiens]
[SimpleEntity:6789198] GlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2 [peptidoglycan-based cell wall]
isChimericFALSE
literatureReference[LiteratureReference:6789121] Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity
[LiteratureReference:6799827] Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences
[Book:8933045] Peptidoglycan Recognition Proteins and Lysozyme Encyclopedia of Immunobiology Ratcliffe, Michael 9780123742797
modified[InstanceEdit:6799831] Shamovsky, Veronica, 2015-09-26
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8931789] Shamovsky, Veronica, 2016-07-19
[InstanceEdit:8933042] Shamovsky, Veronica, 2016-08-02
[InstanceEdit:8935890] Shamovsky, Veronica, 2016-08-15
[InstanceEdit:8936377] Shamovsky, Veronica, 2016-08-18
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9836317] D'Eustachio, Peter, 2023-05-25
namePGLYRP1 binds bacterial peptidoglycan
output[Complex:6789175] PGLYRP1dimer:peptidoglycan [phagocytic vesicle lumen] [Homo sapiens]
regulatedBy[PositiveRegulation:6799969] Positive regulation by 'Zn2+ [phagocytic vesicle lumen]'
regulationReference[RegulationReference:9642817] Positive regulation by 'Zn2+ [phagocytic vesicle lumen]' Human peptidoglycan recognition proteins require zinc to kill both gram-positive and gram-negative bacteria and are synergistic with antibacterial peptides
releaseDate2016-09-19
reviewed[InstanceEdit:8933043] Dziarski, Roman, 2016-08-02
[InstanceEdit:8933035] Hains, David S, 2016-08-02
[InstanceEdit:8867536] Jupe, Steve, 2016-04-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8891929] R-HSA-6789072.5
summation[Summation:6799823] Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are in...
(hasEvent)[Pathway:6803157] Antimicrobial peptides [Homo sapiens]
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No pathways have been reviewed or authored by PGLYRP1 binds bacterial peptidoglycan (6789072)
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