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Details on Person Phagocytic cells kill microorganisms by ingesting them into ...
| Class:Id | Summation:6789009 |
|---|---|
| _displayName | Phagocytic cells kill microorganisms by ingesting them into ... |
| _timestamp | 2018-10-18 04:52:51 |
| created | [InstanceEdit:6789177] Shamovsky, Veronica, 2015-07-29 |
| literatureReference | [LiteratureReference:6789006] The human NADPH oxidase: primary and secondary defects impairing the respiratory burst function and the microbicidal ability of phagocytes [LiteratureReference:6789171] VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification [LiteratureReference:6789004] Physiological roles of voltage-gated proton channels in leukocytes [LiteratureReference:6789139] Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing [LiteratureReference:6788995] Impaired macrophage function following bacterial stimulation in chronic granulomatous disease [LiteratureReference:6789026] The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes [LiteratureReference:9625026] Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis |
| modified | [InstanceEdit:6807657] Shamovsky, Veronica, 2015-11-03 [InstanceEdit:9625028] Shamovsky, Veronica, 2018-10-18 |
| text | Phagocytic cells kill microorganisms by ingesting them into phagocytic vacuoles (phagosomes). Phagocytosis is accompanied by the activation of the NADPH oxidase (NOX2 complex), a multiprotein enzyme complex, that assembles in the phagosomal membrane (Winterbourn C et al. 2006). The NOX2 complex shuttles electrons from NADPH in the cytoplasm across the membrane to oxygen in the phagosomal lumen converting oxygen into the superoxide radical anion (O2.-). As this electron transfer creates a charge imbalance that would otherwise depolarize the membrane, NADPH oxidase activity is accompanied by activation of the V-ATPase and voltage-gated proton channel (Demaurex N & El Chemaly A 2010; El Chemaly A et al. 2010; Nunes P et al. 2013). Defects in NADPH oxidase components are associated with chronic granulomatous disease (CGD) (de Oliveira-Junior EB et al. 2011). Phagocytic cells of CGD patients are unable to produce superoxide ion, and their efficiency in bacterial killing is significantly impaired (Johnston RB Jr et al. 1975; de Oliveira-Junior EB et al. 2011). In addition, macrophages from CGD patients exhibit abnormal function because these cells release higher levels of anti-inflammatory cytokines and lower levels of proinflammatory cytokines in response to bacterial stimuli (Rahman FZ et al. 2009). |
| (summation) | [Reaction:6789092] NOX2 generates superoxide anion from oxygen [Homo sapiens] |
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