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Details on Person The complex of ATR and ATRIP (ATR:ATRIP) is recruited to rep...
| Class:Id | Summation:6788380 |
|---|---|
| _displayName | The complex of ATR and ATRIP (ATR:ATRIP) is recruited to rep... |
| _timestamp | 2015-08-26 04:13:18 |
| created | [InstanceEdit:6788375] Orlic-Milacic, Marija, 2015-07-20 |
| modified | [InstanceEdit:6788504] Orlic-Milacic, Marija, 2015-07-22 [InstanceEdit:6792730] Orlic-Milacic, Marija, 2015-08-26 |
| text | The complex of ATR and ATRIP (ATR:ATRIP) is recruited to replication forks blocked by DNA interstrand crosslinks (ICL-DNA) through interaction with the RPA complex and the Fanconi anemia (FA) core complex. The RPA heterotrimer associates both with single strand DNA (ssDNA) that is produced by DNA resection at ICL-DNA-stalled replication forks and with the FANCM and FAAP24 components of the FA core complex (Huang et al. 2010). ATRIP directly interacts with the FANCL component of the FA core complex (Tomida et al. 2013). The presence of RAD17 and TOPB1, which is required for ATR activation at DNA double strand breaks (DSBs), is not needed for ATR activation at ICL-DNA (Tomida et al. 2013). |
| (summation) | [Reaction:6788385] The complex of ATR and ATRIP is recruited to ICL-DNA [Homo sapiens] |
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No pathways have been reviewed or authored by The complex of ATR and ATRIP (ATR:ATRIP) is recruited to rep... (6788380)
