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Details on Person Diagram of Interleukin-17 signaling
| Class:Id | PathwayDiagram:6787776 |
|---|---|
| _displayName | Diagram of Interleukin-17 signaling |
| _timestamp | 2022-05-10 22:06:40 |
| created | [InstanceEdit:6787778] Jupe, Steve, 2015-07-17 |
| height | 1859 |
| modified | [InstanceEdit:6787824] Jupe, Steve, 2015-07-17 [InstanceEdit:6787843] Jupe, Steve, 2015-07-17 [InstanceEdit:8854660] Jupe, Steve, 2016-01-28 [InstanceEdit:8861824] Matthews, Lisa, 2016-02-21 [InstanceEdit:8951038] Duenas, Corina, 2016-12-02 [InstanceEdit:8980523] Duenas, Corina, 2017-02-27 [InstanceEdit:8980563] Duenas, Corina, 2017-02-28 [InstanceEdit:8980638] Duenas, Corina, 2017-02-28 [InstanceEdit:8980867] Duenas, Corina, 2017-03-01 [InstanceEdit:8983619] Duenas, Corina, 2017-03-27 [InstanceEdit:8983817] Duenas, Corina, 2017-03-29 [InstanceEdit:8983825] Duenas, Corina, 2017-03-29 [InstanceEdit:8983953] Duenas, Corina, 2017-03-31 [InstanceEdit:8986371] Duenas, Corina, 2017-04-25 [InstanceEdit:8986378] Duenas, Corina, 2017-04-26 [InstanceEdit:8986379] Duenas, Corina, 2017-04-26 [InstanceEdit:9005955] Duenas, Corina, 2017-05-11 [InstanceEdit:9015011] Duenas, Corina, 2017-08-08 [InstanceEdit:9015115] Duenas, Corina, 2017-08-08 [InstanceEdit:9015183] Duenas, Corina, 2017-08-09 [InstanceEdit:9715972] Stephan, Ralf, 2021-02-19 [InstanceEdit:9767830] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9768027] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9773908] Shamovsky, Veronica, 2022-05-10 |
| representedPathway | [Pathway:448424] Interleukin-17 signaling [Homo sapiens] |
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textPosition="936 535" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TNFAIP3:2xIL17A,2xIL17F,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1144" reactomeId="174211" position="1125 648" bounds="1090 637 70 22" textPosition="1097 637"> <Properties> <displayName>ANAPC5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1145" reactomeId="8980294" position="1209 556" bounds="1119 524 180 64" textPosition="1121 524" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ANAPC5:TNFAIP3:2xIL17A,2xIL17F,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1177" reactomeId="29370" position="1671 1139" bounds="1651 1124 40 30" textPosition="1655 1128" /> <org.gk.render.RenderableProtein id="1187" reactomeId="8980011" position="321 1401" bounds="291 1390 60 22" textPosition="299 1390"> <Properties> <displayName>CEBPB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1188" reactomeId="8980079" position="418 1411" bounds="369 1398 98 26" textPosition="369 1400"> <Properties> <displayName>p-T188-CEBPB</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.9835150496378953" label="P" description="Thr" trackId="0" reactomeId="8979987" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1205" reactomeId="8980215" position="667 1431" bounds="612 1413 111 36" textPosition="618 1413"> <Properties> <displayName>p-T188,T179-CEBPB</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.3445187576011889" relativeY="1.0" label="P" description="Thr" trackId="0" reactomeId="8979987" /> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.5364885997150374" label="P" description="Thr" trackId="1" reactomeId="8979990" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1212" reactomeId="8980070" position="419 1520" bounds="379 1502 80 36" textPosition="388 1502"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.7360676464130309" relativeY="0.0" label="P" description="Thr" trackId="0" reactomeId="8979987" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1213" reactomeId="30150" position="416 1609" bounds="353 1594 126 31" textPosition="360 1592"> <Properties> <displayName>Double-stranded DNA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1214" reactomeId="8980071" position="628 1616" bounds="562 1607 132 19" textPosition="564 1604" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-T188-CEBPB:DNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1243" reactomeId="8980173" position="5628 583" bounds="5561 565 134 36" textPosition="5574 565" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>2xIL17E:IL17RA:IL17RB:TRAF3IP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1245" reactomeId="8979712" position="5547 684" bounds="5512 673 71 22" textPosition="5515 673" /> <org.gk.render.RenderableComplex id="1256" reactomeId="8980171" position="5329 593" bounds="5260 575 138 37" textPosition="5261 576" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL25 dimer:IL17RA:p-Y444,Y454-IL17RB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1283" reactomeId="380747" position="5296 697" bounds="5264 687 65 20" textPosition="5269 686"> <Properties> <displayName>STAT5A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1284" reactomeId="8980444" position="5178 602" bounds="5115 578 127 49" textPosition="5118 577" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL25 dimer:IL17RA:p-Y444,Y454-IL17RB:STAT5A</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1307" reactomeId="8980214" position="5022 595" bounds="4937 578 170 35" textPosition="4937 577" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-STAT5A:2xIL17E:IL17RA:p-Y444,Y454-IL17RB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1308" reactomeId="113592" position="5166 677" bounds="5145 662 42 30" textPosition="5150 666" /> <org.gk.render.RenderableChemical id="1309" reactomeId="29370" position="5028 680" bounds="5007 665 43 30" textPosition="5012 669" /> <org.gk.render.RenderableProtein id="1321" reactomeId="447144" position="89 630" bounds="61 619 57 22" textPosition="64 619"> <Properties> <displayName>IL17RD</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1322" reactomeId="8980094" position="81 679" bounds="28 668 107 22" textPosition="34 668" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL17RA:IL17RD</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1347" reactomeId="8980174" position="5778 583" bounds="5702 567 153 32" textPosition="5704 563" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>2xIL17E:IL17RA:IL17RB:TRAF3IP2:TRAF6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1349" reactomeId="166366" position="5681 678" bounds="5656 667 50 22" textPosition="5658 667"> <Properties> <displayName>TRAF6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1368" reactomeId="8980176" position="6550 595" bounds="6492 577 116 36" textPosition="6501 563" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL17C dimer:IL17RA:IL17RE:TRAF3IP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1370" reactomeId="8979712" position="6422 704" bounds="6387 693 71 22" textPosition="6390 693" /> <org.gk.render.ProcessNode id="1474" reactomeId="450294" position="901 1471" bounds="775 1438 252 67" textPosition="831 1456"> <Properties> <displayName>MAP kinase activation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="1512" reactomeId="113592" position="5466 678" bounds="5447 663 39 30" textPosition="5451 667" /> <org.gk.render.RenderableChemical id="1513" reactomeId="29370" position="5370 688" bounds="5350 673 41 30" textPosition="5354 677" /> <org.gk.render.RenderableChemical id="1541" reactomeId="113592" position="296 1287" bounds="277 1272 39 30" textPosition="281 1276" /> <org.gk.render.RenderableChemical id="1553" reactomeId="29370" position="410 1290" bounds="390 1275 41 30" textPosition="394 1279" /> <org.gk.render.RenderableComplex id="1573" reactomeId="8983572" position="539 1283" bounds="485 1264 109 38" textPosition="488 1266" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-T188-CEBPB:GSK3B</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1576" reactomeId="113592" position="527 1194" bounds="497 1179 60 30" textPosition="511 1183" /> <org.gk.render.RenderableComplex id="1577" reactomeId="8983568" position="674 1283" bounds="615 1266 118 35" textPosition="625 1265" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-T188,T179-CEBPB:GSK3B</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1580" reactomeId="29370" position="672 1195" bounds="642 1180 60 30" textPosition="656 1184"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="1581" reactomeId="5082379" position="413 777" bounds="367 759 93 36" textPosition="367 759"> <Properties> <displayName>HSPA (HSP70) proteins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1583" reactomeId="2997551" position="531 1382" bounds="499 1372 64 20" textPosition="508 1371"> <Properties> <displayName>GSK3B</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1594" reactomeId="8983581" position="2940 798" bounds="2844 766 192 65" textPosition="2844 767" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1622" reactomeId="8983579" position="712 545" bounds="648 504 128 82" textPosition="653 508" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6:IKBKE</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1625" reactomeId="113592" position="709 693" bounds="679 678 60 30" textPosition="693 682"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1636" reactomeId="8983582" position="858 560" bounds="786 521 145 79" textPosition="790 522" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:IKBKE</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1638" reactomeId="29370" position="846 692" bounds="816 677 60 30" textPosition="830 681" /> <org.gk.render.RenderableProtein id="1694" reactomeId="450225" position="665 773" bounds="643 764 44 18" textPosition="644 762"> <Properties> <displayName>IKBKE</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1733" reactomeId="8983583" position="1762 566" bounds="1698 525 129 82" textPosition="1703 529" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6:TBK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1745" reactomeId="8983585" position="1973 556" bounds="1895 512 156 89" textPosition="1895 537" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:p-S162,S220,S-TRAF3IP2:TRAF6:TBK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1746" reactomeId="29370" position="1954 680" bounds="1924 665 60 30" textPosition="1938 669" /> <org.gk.render.RenderableChemical id="1986" reactomeId="113592" position="1812 678" bounds="1775 666 75 24" textPosition="1797 667" /> <org.gk.render.RenderableEntity id="2051" reactomeId="450152" position="3213 761" bounds="3174 750 79 22" textPosition="3177 750" /> <org.gk.render.RenderableProtein id="2052" reactomeId="447225" position="6170 415" bounds="6146 404 49 22" textPosition="6146 404"> <Properties> <displayName>IL17RE</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2054" reactomeId="447176" position="6172 367" bounds="6147 356 51 22" textPosition="6148 356"> <Properties> <displayName>IL17RA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2056" reactomeId="447176" position="5897 586" bounds="5872 575 51 22" textPosition="5873 575" /> <org.gk.render.ProcessNode id="2108" reactomeId="5684996" position="268 1472" bounds="202 1447 133 50" textPosition="214 1450"> <Properties> <displayName>MAPK1/MAPK3 signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntitySet id="2148" reactomeId="9716014" position="151 448" bounds="104 436 95 24" textPosition="121 430" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>IL17A inhibitors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2149" reactomeId="9716003" position="93 317" bounds="33 292 120 51" textPosition="33 293" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>IL17A inhibitors:IL17A dimer;IL17A:IL17F;IL17F dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProteinDrug id="2181" reactomeId="9715965" position="49 529" bounds="4 515 90 29" textPosition="9 518" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>brodalumab</displayName> </Properties> </org.gk.render.RenderableProteinDrug> <org.gk.render.RenderableComplex id="2182" reactomeId="9716009" position="93 756" bounds="51 738 84 37" textPosition="51 739" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>brodalumab:IL17RA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="2189" reactomeId="9705683" position="541 465" bounds="479 443 125 45" textPosition="479 443" isForDisease="true" lineColor="255 0 0"> <Properties> <displayName>SARS-CoV-2-host interactions</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="2190" reactomeId="9755355" position="414 465" bounds="383 454 62 23" textPosition="383 455" bgColor="204 255 255" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>8:IL17RA</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="55" reactomeId="447219" points="5926 509, 5485 550, 5485 574" position="5485 550" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="160" points="5922 358" /> <Input id="659" points="5968 573" /> <Input id="2056" points="5901 572" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> <Properties> <displayName>IL17RA and IL17RB bind IL25 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="84" reactomeId="447246" points="200 506, 239 509, 252 529" position="239 509" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="565" points="170 567" /> <Input id="85" points="311 424, 178 496" /> <Input id="564" points="119 572" /> </Inputs> <Outputs> <Output id="87" /> </Outputs> <Activators> <Activator id="2190" points="380 472" /> </Activators> <Properties> <displayName>IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="282" reactomeId="5678544" points="6369 453, 6410 551, 6414 573" position="6410 551" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="286" points="6290 368" /> <Input id="2052" points="6198 419" /> <Input id="2054" points="6197 381" /> </Inputs> <Outputs> <Output id="285" /> </Outputs> <Properties> <displayName>IL17RA:IL17RE binds IL17C dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="438" reactomeId="8951040" points="262 216, 263 274, 263 304" position="263 274" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="439" /> </Inputs> <Outputs> <Output id="440" /> </Outputs> <Properties> <displayName>IL17A dimer translocates from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="441" points="283 346, 322 378" position="302 362" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="440" /> </Inputs> <Outputs> <Output id="85" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="442" reactomeId="8951071" points="420 216, 420 277, 418 305" position="420 277" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="443" /> </Inputs> <Outputs> <Output id="444" /> </Outputs> <Properties> <displayName>IL17F dimer translocates from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="445" points="397 346, 357 378" position="377 362" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="444" /> </Inputs> <Outputs> <Output id="85" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="446" reactomeId="8951054" points="342 214, 342 272, 341 304" position="342 272" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="447" /> </Inputs> <Outputs> <Output id="448" /> </Outputs> <Properties> <displayName>IL17A:IL17F translocates from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="449" points="340 332, 340 378" position="340 355" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="448" /> </Inputs> <Outputs> <Output id="85" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="450" reactomeId="8951070" points="5922 228, 5921 293, 5921 318" position="5921 293" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="451" /> </Inputs> <Outputs> <Output id="160" /> </Outputs> <Properties> <displayName>IL25 dimer translocates from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="452" reactomeId="8951067" points="6027 237, 6027 301, 6029 336" position="6027 301" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="453" /> </Inputs> <Outputs> <Output id="454" /> </Outputs> <Properties> <displayName>IL17B dimer translocates from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="455" reactomeId="8951069" points="6270 243, 6273 290, 6275 330" position="6273 290" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="456" /> </Inputs> <Outputs> <Output id="286" /> </Outputs> <Properties> <displayName>IL17C dimer translocates from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="457" reactomeId="8951052" points="6406 245, 6405 286, 6405 327" position="6405 286" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="458" /> </Inputs> <Outputs> <Output id="459" /> </Outputs> <Properties> <displayName>IL17D dimer translocates from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="658" reactomeId="8951042" points="6019 505, 6058 527, 6075 571" position="6058 527" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="454" points="6029 374" /> <Input id="659" stoichiometry="2" points="5980 573" /> </Inputs> <Outputs> <Output id="660" /> </Outputs> <Properties> <displayName>IL17RB dimer binds IL17B dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="668" reactomeId="8951104" points="310 621, 354 620, 369 603" position="354 620" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="669" points="308 637" /> <Input id="87" points="291 597" /> </Inputs> <Outputs> <Output id="672" /> </Outputs> <Inhibitors> <Inhibitor id="744" points="377 639" /> </Inhibitors> <Properties> <displayName>TRAF3IP2 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="681" reactomeId="8980293" points="447 657, 503 656, 532 609" position="503 656" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="682" points="429 687" /> <Input id="672" points="412 603" /> </Inputs> <Outputs> <Output id="683" /> </Outputs> <Inhibitors> <Inhibitor id="741" points="483 643" /> </Inhibitors> <Activators> <Activator id="1033" points="520 753" /> <Activator id="1581" points="426 753" /> </Activators> <Properties> <displayName>TRAF6 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="689" reactomeId="8980295" points="1079 697, 1126 683, 1290 683, 1352 593" position="1126 683" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="683" points="620 589" /> <Input id="787" points="1045 721" /> <Input id="784" points="1008 698" /> </Inputs> <Outputs> <Output id="690" /> </Outputs> <Catalysts> <Catalyst id="683" points="620 586" /> </Catalysts> <Inhibitors> <Inhibitor id="772" points="1166 704" /> <Inhibitor id="1132" points="1048 602" /> <Inhibitor id="1145" points="1188 591" /> </Inhibitors> <Properties> <displayName>Ubiquitylation of TRAF6 by TRAF3IP2 after IL17:IL17R interaction</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="708" reactomeId="8980328" points="728 643, 767 643, 814 643" position="767 643" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1622" points="718 589" /> <Input id="1625" stoichiometry="3" points="714 675" /> </Inputs> <Outputs> <Output id="1636" points="837 603" /> <Output id="1638" stoichiometry="3" points="836 674" /> </Outputs> <Catalysts> <Catalyst id="1622" points="735 589" /> </Catalysts> <Properties> <displayName>IKBKE phosphorylates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="712" reactomeId="8980491" points="1835 632, 1882 633, 1928 632" position="1882 633" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1733" points="1807 610" /> <Input id="1986" stoichiometry="3" points="1818 663" /> </Inputs> <Outputs> <Output id="1746" stoichiometry="3" points="1945 662" /> <Output id="1745" points="1946 604" /> </Outputs> <Catalysts> <Catalyst id="1733" points="1830 602" /> </Catalysts> <Properties> <displayName>TBK1 phosphorylates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6:TBK1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="731" reactomeId="8980322" points="2558 683, 3030 680, 3088 613" position="3030 680" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="732" points="2516 708" /> <Input id="710" points="2559 620" /> </Inputs> <Outputs> <Output id="733" /> </Outputs> <Properties> <displayName>TRAF2 binds TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="734" reactomeId="8980327" points="3115 655, 3197 654, 3250 611" position="3197 654" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="733" points="3116 613" /> <Input id="735" points="3097 664" /> </Inputs> <Outputs> <Output id="736" /> </Outputs> <Properties> <displayName>TRAF5 binds TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:TRAF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="766" reactomeId="8980320" points="3281 746, 3330 702, 3428 611" position="3330 702" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="736" points="3288 611" /> <Input id="2051" points="3256 752" /> </Inputs> <Outputs> <Output id="767" /> </Outputs> <Inhibitors> <Inhibitor id="773" points="3326 831" /> </Inhibitors> <Properties> <displayName>TRAF3IP2 K63-ubiquitinates TRAF5 in IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:TRAF2:TRAF5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="866" reactomeId="8980352" points="1472 622, 1506 624, 1518 592" position="1506 624" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="867" points="1428 643" /> <Input id="690" points="1436 593" /> </Inputs> <Outputs> <Output id="868" /> </Outputs> <Inhibitors> <Inhibitor id="1094" points="1396 1075" /> </Inhibitors> <Properties> <displayName>TAK1:TAB2:TAB3 complex binds K63-polyUb-TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="909" reactomeId="8980436" points="3363 644, 3508 644, 3577 627" position="3508 644" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="910" points="3362 770" /> <Input id="736" points="3325 611" /> </Inputs> <Outputs> <Output id="911" /> </Outputs> <Properties> <displayName>SRSF1 binds TRAF2 or TRAF5 in IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S,3Hyp-TRAF3IP2:TRAF2:TRAF5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="924" reactomeId="8980398" points="3455 860, 3455 882, 3455 923" position="3455 882" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="925" points="3571 793" /> <Input id="910" points="3375 798" /> </Inputs> <Outputs> <Output id="926" /> </Outputs> <Properties> <displayName>SRSF1 binds CXCL1 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="939" reactomeId="8980412" points="3981 621, 4043 661, 4139 625" position="4043 661" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="940" /> </Inputs> <Outputs> <Output id="941" /> </Outputs> <Catalysts> <Catalyst id="940" points="3936 621, 3941 660" /> </Catalysts> <Properties> <displayName>ELAVL1 is polyubiquitinated by TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:TRAF2:TRAF5:ELAVL1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="946" reactomeId="8980409" points="3541 685, 3884 686, 3916 621" position="3884 686" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="947" points="3479 708" /> <Input id="736" points="3366 611" /> </Inputs> <Outputs> <Output id="940" /> </Outputs> <Properties> <displayName>ELAVL1 binds TRAF2 or TRAF5 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:TRAF2:TRAF5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="996" reactomeId="8980411" points="4204 778, 4442 779, 4501 628" position="4442 779" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="941" points="4210 625" /> <Input id="925" points="3653 779" /> </Inputs> <Outputs> <Output id="997" /> </Outputs> <Properties> <displayName>CXCL1 mRNA binds ELAVL1 or TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:TRAF2:TRAF5:K63polyUb-ELAVL1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1061" reactomeId="8980376" points="2743 664, 2742 626, 2744 604" position="2742 626" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="710" points="2634 607" /> <Input id="1062" points="2743 705" /> </Inputs> <Outputs> <Output id="1063" /> </Outputs> <Properties> <displayName>SCF-beta-TrCp1,2 binds TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1075" reactomeId="8980457" points="2787 604, 2819 636, 2842 622" position="2819 636" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1063" /> </Inputs> <Outputs> <Output id="1076" /> </Outputs> <Catalysts> <Catalyst id="1063" points="2759 604, 2768 633" /> </Catalysts> <Properties> <displayName>SCF-beta-TrCp1,2 K48 polyubiquitinates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF6:p-S162,S220,S-TRAF3IP2:(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1081" reactomeId="8980397" points="3394 938, 3360 935, 3361 798" position="3360 935" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="926" /> </Inputs> <Outputs> <Output id="910" /> </Outputs> <Properties> <displayName>Degradation of CXCL1 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1104" reactomeId="8980339" points="1602 1060, 1602 1087, 1601 1120" position="1602 1087" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1105" points="1601 997" /> <Input id="1106" stoichiometry="2" points="1632 1041" /> </Inputs> <Outputs> <Output id="1108" points="1509 1223" /> <Output id="1177" stoichiometry="2" points="1648 1133" /> </Outputs> <Catalysts> <Catalyst id="868" points="1534 592, 1532 1060" /> </Catalysts> <Inhibitors> <Inhibitor id="1094" points="1427 1090" /> </Inhibitors> <Properties> <displayName>Phosphorylation of IKK complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1130" reactomeId="8980383" points="1272 601, 1134 605, 1104 593" position="1134 605" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="690" points="1316 576" /> <Input id="1131" points="1271 620" /> </Inputs> <Outputs> <Output id="1132" /> </Outputs> <Properties> <displayName>TNFAIP3 binds IL17RA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1143" reactomeId="8980387" points="1131 618, 1154 617, 1180 591" position="1154 617" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1132" points="1090 602" /> <Input id="1144" points="1127 634" /> </Inputs> <Outputs> <Output id="1145" /> </Outputs> <Properties> <displayName>ANAPC5 binds TNFAIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1176" reactomeId="8980487" points="2931 629, 2928 725, 2934 763" position="2928 725" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1076" /> </Inputs> <Outputs> <Output id="1594" /> </Outputs> <Properties> <displayName>p-polyUbK48-TRAF3IP2 degradation by SCF complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1186" reactomeId="8980361" points="353 1355, 379 1357, 407 1358" position="379 1357" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1541" points="308 1305" /> <Input id="1187" points="328 1387" /> </Inputs> <Outputs> <Output id="1188" points="415 1395" /> <Output id="1553" points="409 1308" /> </Outputs> <Catalysts> <Catalyst id="1187" points="335 1387" /> </Catalysts> <Properties> <displayName>CEBPB is phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1202" reactomeId="8980479" points="549 1243, 607 1243, 656 1244" position="607 1243" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1573" points="543 1261" /> <Input id="1576" points="533 1212" /> </Inputs> <Outputs> <Output id="1577" points="665 1263" /> <Output id="1580" points="667 1213" /> </Outputs> <Catalysts> <Catalyst id="1573" points="571 1261" /> </Catalysts> <Properties> <displayName>p-T188-CEBPB is phosphorylated by activated GSK3B</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1211" reactomeId="8980362" points="505 1558, 567 1557, 618 1604" position="567 1557" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1212" points="462 1537" /> <Input id="1213" points="443 1591" /> </Inputs> <Outputs> <Output id="1214" /> </Outputs> <Inhibitors> <Inhibitor id="1205" points="667 1452, 671 1525" /> </Inhibitors> <Properties> <displayName>p-T188-CEBPB binds DNA for transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1217" reactomeId="8980359" points="418 1427, 419 1463, 419 1499" position="419 1463" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1188" /> </Inputs> <Outputs> <Output id="1212" /> </Outputs> <Properties> <displayName>p-T188-CEBPB translocates from cytosol to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1242" reactomeId="8980261" points="5586 642, 5628 643, 5628 604" position="5628 643" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="58" points="5524 616" /> <Input id="1245" points="5557 670" /> </Inputs> <Outputs> <Output id="1243" /> </Outputs> <Properties> <displayName>IL25 dimer:IL17RA:IL17RB binds TRAF3IP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1254" reactomeId="8980273" points="5451 651, 5420 651, 5391 650" position="5420 651" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="58" points="5474 616" /> <Input id="1512" points="5457 660" /> </Inputs> <Outputs> <Output id="1513" points="5378 670" /> <Output id="1256" points="5349 615" /> </Outputs> <Catalysts> <Catalyst id="58" points="5464 616" /> </Catalysts> <Properties> <displayName>IL17RB in IL25 dimer:IL17RA:IL17RB is phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1282" reactomeId="8980445" points="5293 661, 5237 658, 5203 630" position="5237 658" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1256" points="5319 615" /> <Input id="1283" points="5295 684" /> </Inputs> <Outputs> <Output id="1284" /> </Outputs> <Properties> <displayName>STAT5A binds IL25 dimer:IL17RA:p-Y444,Y454-IL17RB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1306" reactomeId="8980443" points="5148 646, 5100 645, 5067 646" position="5100 645" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1308" points="5157 659" /> <Input id="1284" points="5161 630" /> </Inputs> <Outputs> <Output id="1307" points="5037 616" /> <Output id="1309" points="5045 662" /> </Outputs> <Catalysts> <Catalyst id="1284" points="5133 630" /> </Catalysts> <Properties> <displayName>STAT5A in IL25 dimer:IL17RA:p-Y444,Y454-IL17RB:STAT5A is phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1320" reactomeId="8980274" points="166 622, 166 674, 138 675" position="166 674" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="564" points="125 600" /> <Input id="1321" points="121 627" /> </Inputs> <Outputs> <Output id="1322" /> </Outputs> <Properties> <displayName>IL17RA binds IL17RD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1346" reactomeId="8980494" points="5702 646, 5764 646, 5774 602" position="5764 646" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1243" points="5649 604" /> <Input id="1349" points="5688 664" /> </Inputs> <Outputs> <Output id="1347" /> </Outputs> <Properties> <displayName>TRAF6 binds TRAF3IP2 from complex IL17E:IL17E Receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1367" reactomeId="8980460" points="6444 657, 6526 658, 6543 616" position="6526 658" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="285" points="6425 615" /> <Input id="1370" points="6427 690" /> </Inputs> <Outputs> <Output id="1368" /> </Outputs> <Properties> <displayName>TRAF3IP2 binds IL17C:IL17CReceptor complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1582" reactomeId="8983601" points="447 1377, 476 1348, 520 1305" position="476 1348" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1583" points="496 1380" /> <Input id="1188" points="429 1395" /> </Inputs> <Outputs> <Output id="1573" /> </Outputs> <Properties> <displayName>GSK3B binds p-T188-CEBPB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1593" reactomeId="8983594" points="671 1304, 662 1379, 662 1379" position="662 1379" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1577" /> </Inputs> <Outputs> <Output id="1583" points="566 1381" /> <Output id="1205" points="665 1410" /> </Outputs> <Properties> <displayName>GSK3B dissociates from p-T188,p-179-CEBPB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1693" reactomeId="8983597" points="602 700, 639 697, 692 589" position="639 697" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1694" points="657 761" /> <Input id="683" points="564 609" /> </Inputs> <Outputs> <Output id="1622" /> </Outputs> <Properties> <displayName>IKBKE binds TRAF3IP2 in IL17RA:IL17RC:IL17A dimer, IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1695" reactomeId="8983592" points="870 603, 923 759, 2227 776" position="923 759" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1636" /> </Inputs> <Outputs> <Output id="1694" points="690 773" /> <Output id="710" points="2486 614" /> </Outputs> <Properties> <displayName>IKBKE dissociates from IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1765" reactomeId="8983593" points="600 792, 1637 790, 1739 610" position="1637 790" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="683" points="559 609" /> <Input id="716" points="2059 833" /> </Inputs> <Outputs> <Output id="1733" /> </Outputs> <Properties> <displayName>TBK1 binds a TRAF3IP2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1766" reactomeId="8983600" points="2028 604, 2164 708, 2205 710" position="2164 708" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1745" /> </Inputs> <Outputs> <Output id="714" points="2301 609" /> <Output id="716" points="2093 820" /> </Outputs> <Properties> <displayName>TBK1 dissociates from a TRAF3IP2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2097" interactionType="Activate" points="1488 1260, 1405 1436" position="1446 1348" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1108" /> </Inputs> <Outputs> <Output id="879" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2109" interactionType="Activate" points="270 597, 268 1444" position="269 1020" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="87" /> </Inputs> <Outputs> <Output id="2108" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2110" interactionType="Activate" points="1392 1436, 1391 1108" position="1391 1272" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="879" /> </Inputs> <Outputs> <Output id="1094" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2147" reactomeId="9715990" points="166 400, 166 400, 115 346" position="166 400" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="85" points="277 400" /> <Input id="2148" points="154 430" /> </Inputs> <Outputs> <Output id="2149" /> </Outputs> <Properties> <displayName>IL17A inhibitors bind to IL17A dimer;IL17A:IL17F;IL17F dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2180" reactomeId="9716007" points="17 599, 17 600, 17 717, 56 735" position="17 600" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="564" points="79 589" /> <Input id="2181" points="42 547" /> </Inputs> <Outputs> <Output id="2182" /> </Outputs> <Properties> <displayName>Brodalumab binds to IL17RA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2192" interactionType="Activate" points="476 464, 448 464" position="462 464" lineWidth="2.0"> <Inputs> <Input id="2189" /> </Inputs> <Outputs> <Output id="2190" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Interleukin-17 signaling (6787776)
