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Details on Person The granulocyte colony-stimulating factor receptor (CSF3R, G...

Class:IdSummation:6787736
_displayNameThe granulocyte colony-stimulating factor receptor (CSF3R, G...
_timestamp2020-03-09 11:26:13
created[InstanceEdit:6787740] Jupe, Steve, 2015-07-16
literatureReference[LiteratureReference:6787732] Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains
[LiteratureReference:8854733] Evidence for the ligand-induced conversion from a dimer to a tetramer of the granulocyte colony-stimulating factor receptor
[LiteratureReference:6787727] Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis
[LiteratureReference:8854722] Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme
[LiteratureReference:8854727] Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex
[LiteratureReference:6787730] Kostmann syndrome and severe congenital neutropenia
[LiteratureReference:6787739] Severe congenital neutropenia, a genetically heterogeneous disease group with an increased risk of AML/MDS
[LiteratureReference:8854741] The interaction of G-CSF with its receptor
modified[InstanceEdit:6787769] Jupe, Steve, 2015-07-17
[InstanceEdit:6801270] Garapati, Phani Vijay, 2015-10-01
[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
[InstanceEdit:8854754] Jupe, Steve, 2016-01-28
[InstanceEdit:9677623] May, Bruce, 2020-03-09
textThe granulocyte colony-stimulating factor receptor (CSF3R, GCSFR, CD114) is a cell-surface receptor for the granulocyte colony-stimulating factor (CSF3, GCSF) (Larsen et al. 1990, Panopoulos & Watowich 2008). It is present on precursor cells in the bone marrow. CSF3 initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

CSF3 exists as a dimer and higher order oligomeric structures; only the dimer exhibits high affinity binding (Hiraoka & Anaguchi et al. 1994). CSF3R ligand-binding is associated with dimerization of the receptor (Aritomi et al. 1999, Tamada et al. 2006, Layton & Hall 2006) and signal transduction through Jak/STAT, Lyn and Erk1/2. Mutations in CSF3R are a cause of Kostmann syndrome, also known as severe congenital neutropenia (Zeidler & Welte 2002, Vandenberghe & Beel 2011).
(summation)[Reaction:6787737] CSF3R binds CSF3 dimer [Homo sapiens]
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