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Details on Person UniProt:Q9UQR1 ZNF148
| Class:Id | ReferenceGeneProduct:67864 |
|---|---|
| _chainChangeLog | chain:1-794 added on Sat February 7 2015 |
| _displayName | UniProt:Q9UQR1 ZNF148 |
| _timestamp | 2024-11-03 19:39:44 |
| chain | chain:1-794 |
| checksum | 50413723459EBD1F |
| comment | FUNCTION Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.SUBUNIT Interacts with HNRNPDL (PubMed:15190078). Interacts with the 5FMC complex; the interaction requires association with CHTOP. Interacts with CAVIN1 (By similarity).INTERACTION Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the krueppel C2H2-type zinc-finger protein family. |
| description | recommendedName: Zinc finger protein 148 alternativeName: Transcription factor ZBP-89 alternativeName: Zinc finger DNA-binding protein 89 |
| geneName | ZNF148 ZBP89 |
| identifier | Q9UQR1 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing DNA-binding Dwarfism Intellectual disability Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ZNF148 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002760] ENSEMBL:ENSG00000163848 ZNF148 [Homo sapiens] |
| secondaryIdentifier | ZN148_HUMAN D3DN27 O00389 O43591 Q58EY5 Q6PJ98 |
| sequenceLength | 794 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965935] UniProt:Q9UQR1-1 ZNF148 [Homo sapiens] [ReferenceIsoform:8965936] UniProt:Q9UQR1-2 ZNF148 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3261155] ZNF148 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3261159] monoSUMO1-K115,356-ZNF148 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3261194] SUMO3-ZNF148 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3261196] polySUMO2,3-K115,K356-ZNF148 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:3261174] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 115 [GroupModifiedResidue:3261179] sumoylated lysine (polySUMO3 [nucleoplasm]) at 356 [GroupModifiedResidue:3261184] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 356 [GroupModifiedResidue:3261188] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 356 [GroupModifiedResidue:3261195] sumoylated lysine (polySUMO3 [nucleoplasm]) at 115 [GroupModifiedResidue:3261197] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 115 |
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No pathways have been reviewed or authored by UniProt:Q9UQR1 ZNF148 (67864)
