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Details on Person CARNS1 transforms ATP, L-His, b-Ala to CARN

Class:Id	Reaction:6786245
_displayName	CARNS1 transforms ATP, L-His, b-Ala to CARN
_doRelease	TRUE
_timestamp	2024-11-08 15:22:46
authored	[InstanceEdit:6786192] Jassal, Bijay, 2015-07-06
catalystActivity	[CatalystActivity:6786246] carnosine synthase activity of CARNS1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6786249] Jassal, Bijay, 2015-07-06
crossReference	[DatabaseIdentifier:9925987] RHEA:19298
edited	[InstanceEdit:6786192] Jassal, Bijay, 2015-07-06
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29612] L-His [cytosol] [SimpleEntity:73590] b-Ala [cytosol]
internalReviewed	[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
isChimeric	FALSE
literatureReference	[LiteratureReference:6786243] Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)
modified	[InstanceEdit:6786265] Jassal, Bijay, 2015-07-06 [InstanceEdit:6797579] Jassal, Bijay, 2015-09-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925993] D'Eustachio, Peter, 2024-10-29 [InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31 [InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
name	CARNS1 transforms ATP, L-His, b-Ala to CARN ATP + beta-alanine + L-histidine => ADP + carnosine + H(+) + phosphate
output	[SimpleEntity:6786250] CARN [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6797578] D'Eustachio, Peter, 2015-09-14 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812443] R-HSA-6786245.3
structureModified	[InstanceEdit:9925993] D'Eustachio, Peter, 2024-10-29
summation	[Summation:6786248] Carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma...
(hasEvent)	[Pathway:70921] Histidine catabolism [Homo sapiens]
(precedingEvent)	[Reaction:8876789] CARNMT1 methylates CARN to Anserine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9928498] Update Tracker - [Reaction:6786245] CARNS1 transforms ATP, L-His, b-Ala to CARN - v91:[removeOutput]
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