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Details on Person CYP4V2 omega-hydroxylates DHA to HDoHE

Class:Id	Reaction:6786239
_displayName	CYP4V2 omega-hydroxylates DHA to HDoHE
_doRelease	TRUE
_timestamp	2024-04-17 17:51:44
authored	[InstanceEdit:6786192] Jassal, Bijay, 2015-07-06
catalystActivity	[CatalystActivity:6786235] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of CYP4V2 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:6786232] Jassal, Bijay, 2015-07-06
edited	[InstanceEdit:6786192] Jassal, Bijay, 2015-07-06
input	[SimpleEntity:6786220] DHA [endoplasmic reticulum membrane] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:216593] Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2 [LiteratureReference:6786241] Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase [LiteratureReference:6786227] CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant
modified	[InstanceEdit:6786265] Jassal, Bijay, 2015-07-06 [InstanceEdit:6797579] Jassal, Bijay, 2015-09-14 [InstanceEdit:6809409] Jassal, Bijay, 2015-11-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9907889] D'Eustachio, Peter, 2024-04-17
name	CYP4V2 omega-hydroxylates DHA to HDoHE (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced (NADPH--hemoprotein reductase) => 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:6786225] HDoHE [endoplasmic reticulum membrane] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6797578] D'Eustachio, Peter, 2015-09-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812442] R-HSA-6786239.3
summation	[Summation:6786218] The main physiological function of normal retinal photorecep...
(hasEvent)	[Pathway:211976] Endogenous sterols [Homo sapiens] [Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) [Homo sapiens]
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No pathways have been reviewed or authored by CYP4V2 omega-hydroxylates DHA to HDoHE (6786239)