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Details on Person FANCD2 deubiquitination by USP1:WDR48

Class:Id	Reaction:6786171
_displayName	FANCD2 deubiquitination by USP1:WDR48
_doRelease	TRUE
_timestamp	2017-11-13 16:43:28
authored	[InstanceEdit:419516] Matthews, L, 2009-05-02 17:26:55
catalystActivity	[CatalystActivity:420759] cysteine-type deubiquitinase activity of USP1:WDR48 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6786172] Orlic-Milacic, Marija, 2015-07-03
edited	[InstanceEdit:421857] Matthews, L, 2009-05-20 15:51:04
input	[Complex:6785367] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:421859] A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway
modified	[InstanceEdit:6788497] Orlic-Milacic, Marija, 2015-07-21 [InstanceEdit:6788501] Orlic-Milacic, Marija, 2015-07-21 [InstanceEdit:6788502] Orlic-Milacic, Marija, 2015-07-22 [InstanceEdit:6792506] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9028893] Orlic-Milacic, Marija, 2017-11-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FANCD2 deubiquitination by USP1:WDR48
output	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [Complex:6788402] p-FANCD2:p-FANCI [nucleoplasm] [Homo sapiens] [Complex:6788397] p-FA Core Complex:ICL-DNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6785361] Monoubiquitination of FANCD2:FANCI [Homo sapiens] [Reaction:6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA [Homo sapiens]
releaseDate	2009-06-24
reviewed	[InstanceEdit:421862] Huang, TT, 2009-05-20 17:48:24 [InstanceEdit:6792505] Fugger, Kasper, 2015-08-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796981] R-HSA-6786171.3
summation	[Summation:419542] The FA pathway is negatively regulated through the USP1:WDR4...
(hasEvent)	[Pathway:6783310] Fanconi Anemia Pathway [Homo sapiens]
(replacementInstances)	[_Deleted:6793205] Deletion of instance: 419525 [_Deleted:6793362] Deletion of instance: 419552
(updatedInstance)	[_UpdateTracker:9780267] Update Tracker - [Reaction:6786171] FANCD2 deubiquitination by USP1:WDR48 - v63:[modifyText]
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