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Details on Person Translesion synthesis across unhooked ICL by POLN

Class:Id	BlackBoxEvent:6786166
_displayName	Translesion synthesis across unhooked ICL by POLN
_doRelease	TRUE
_timestamp	2015-09-04 20:41:34
authored	[InstanceEdit:6785606] Orlic-Milacic, Marija, 2015-06-29
catalystActivity	[CatalystActivity:6786167] DNA-directed DNA polymerase activity of MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6786159] Orlic-Milacic, Marija, 2015-07-03
edited	[InstanceEdit:6785606] Orlic-Milacic, Marija, 2015-06-29
input	[Complex:6786156] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] [Homo sapiens] [SimpleEntity:30555] dNTP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5686109] DNA polymerase POLN participates in cross-link repair and homologous recombination [LiteratureReference:6786161] Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links [LiteratureReference:6786164] Fanconi anaemia and the repair of Watson and Crick DNA crosslinks [LiteratureReference:6786163] DNA interstrand crosslink repair and cancer
modified	[InstanceEdit:6788497] Orlic-Milacic, Marija, 2015-07-21 [InstanceEdit:6792506] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792920] Orlic-Milacic, Marija, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translesion synthesis across unhooked ICL by POLN
output	[SimpleEntity:113541] PPi [nucleoplasm] [OtherEntity:75165] DNA double-strand break ends [nucleoplasm] [OtherEntity:5688114] Distorted dsDNA [nucleoplasm] [Complex:420757] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6786153] POLN [nucleoplasm] [Homo sapiens] [Complex:6788399] p-FA Core Complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6786155] POLN binds ICL-DNA [Homo sapiens] [BlackBoxEvent:6785986] DNA nucleases unhook the interstrand crosslink (ICL) [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6792505] Fugger, Kasper, 2015-08-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797045] R-HSA-6786166.2
summation	[Summation:6786169] The error-prone DNA polymerase nu (POLN) performs translesio...
(hasEvent)	[Pathway:6783310] Fanconi Anemia Pathway [Homo sapiens]
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