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Details on Person UniProt:Q05516 ZBTB16
| Class:Id | ReferenceGeneProduct:67860 |
|---|---|
| _chainChangeLog | chain:1-673 added on Fri February 6 2015 |
| _displayName | UniProt:Q05516 ZBTB16 |
| _timestamp | 2024-11-03 20:17:33 |
| chain | chain:1-673 |
| checksum | 51F8E361FA31239E |
| comment | FUNCTION Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Binds EPN1 (PubMed:11161217). Interacts with ZBTB32 and CUL3 (PubMed:10572087, PubMed:14528312). Interacts with ATP7B (PubMed:16676348). Interacts with transcriptional corepressor RUNX1T1 (via its N-terminus); the interaction increases the transcription repression activity of ZBTB16 (PubMed:10688654). Interacts (via C2H2-type zinc finger domains 1 and 2) with RNF112 (PubMed:24359566).INTERACTION Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.INDUCTION By retinoic acid.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA.SIMILARITY Belongs to the krueppel C2H2-type zinc-finger protein family. |
| description | recommendedName: Zinc finger and BTB domain-containing protein 16 alternativeName: Promyelocytic leukemia zinc finger protein alternativeName: Zinc finger protein 145 alternativeName: Zinc finger protein PLZF |
| geneName | ZBTB16 PLZF ZNF145 |
| identifier | Q05516 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromosomal rearrangement Disease variant DNA-binding Intellectual disability Metal-binding Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ZBTB16 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988218] ENSEMBL:ENSG00000109906 ZBTB16 [Homo sapiens] |
| secondaryIdentifier | ZBT16_HUMAN Q8TAL4 |
| sequenceLength | 673 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:156294] UniProt:Q05516-2 ZBTB16 [Homo sapiens] [ReferenceIsoform:405185] UniProt:Q05516-1 ZBTB16 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:976047] ZBTB16 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5223063] ZBTB16 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q05516 ZBTB16 (67860)
