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Query author contributions in Reactome

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Details on Person Phosphorylated Signal transducer and activator of transcript...

Class:IdSummation:6785853
_displayNamePhosphorylated Signal transducer and activator of transcript...
_timestamp2015-09-10 16:04:42
created[InstanceEdit:6785864] Jupe, Steve, 2015-07-01
literatureReference[LiteratureReference:6786053] Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma
[LiteratureReference:3261236] Signaling mechanisms, interaction partners, and target genes of STAT6
modified[InstanceEdit:6786052] Jupe, Steve, 2015-07-03
[InstanceEdit:6786277] Jupe, Steve, 2015-07-06
[InstanceEdit:6788635] Jupe, Steve, 2015-07-23
[InstanceEdit:6793965] Jupe, Steve, 2015-09-04
[InstanceEdit:6797418] Jupe, Steve, 2015-09-10
textPhosphorylated Signal transducer and activator of transcription 6 (STAT6) dimers translocate to the nucleus and activate the transcription of several genes. In experimental models, targeted gene disruption of STAT6 inhibited airway hyper-responsiveness, airway inflammation, and fibrosis (Blease et al. 2002). STAT6 promotes transcription of the cytoplasmic protein Suppressor of cytokine signaling 1 (SOCS1) (Hebenstreit et al. 2003).
(summation)[BlackBoxEvent:6785860] Expression of SOCS1 [Homo sapiens]
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