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Details on Person PTPRK dephosphorylates p-6Y-EGFR

Class:Id	Reaction:6785705
_displayName	PTPRK dephosphorylates p-6Y-EGFR
_timestamp	2024-03-19 12:24:53
catalystActivity	[CatalystActivity:6785698] protein tyrosine phosphatase activity of PTPRK [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:6785704] Garapati, Phani Vijay, 2015-06-30
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6785333] An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis [LiteratureReference:6785337] Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function
modified	[InstanceEdit:6787697] Garapati, Phani Vijay, 2015-07-15 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9624471] Rothfels, Karen, 2018-10-11 [InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
name	PTPRK dephosphorylates p-6Y-EGFR
negativePrecedingEvent	[NegativePrecedingEvent:9865817] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
output	[SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [Complex:9624420] EGF-like ligands:EGFR dimer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:177937] Phosphorylation of EGFR by SRC kinase [Homo sapiens] [Reaction:177922] EGFR dimerization [Homo sapiens] [Reaction:177934] EGFR autophosphorylation [Homo sapiens] [Reaction:177922] EGFR dimerization [Homo sapiens] [Reaction:9851407] FAM83B, (FAM83A, FAM83D) bind EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8886325] R-HSA-6785705.1
summation	[Summation:6785702] Receptor-type tyrosine-protein phosphatase kappa (PTPRK/RPTP...
(hasEvent)	[Pathway:182971] EGFR downregulation [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9865809] Futile Cycle: PTPRK dephosphorylates p-6Y-EGFR [NegativePrecedingEvent:9865811] Futile Cycle: PTPRK dephosphorylates p-6Y-EGFR [NegativePrecedingEvent:9865816] Futile Cycle: PTPRK dephosphorylates p-6Y-EGFR
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No pathways have been reviewed or authored by PTPRK dephosphorylates p-6Y-EGFR (6785705)