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Details on Person FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex

Class:Id	Reaction:6785342
_displayName	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex
_doRelease	TRUE
_timestamp	2015-09-04 20:36:54
authored	[InstanceEdit:6785606] Orlic-Milacic, Marija, 2015-06-29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6785344] Orlic-Milacic, Marija, 2015-06-26
edited	[InstanceEdit:6785606] Orlic-Milacic, Marija, 2015-06-29
input	[Complex:420764] FANCD2:FANCI [nucleoplasm] [Homo sapiens] [Complex:6785124] FA Core Complex:ICL-DNA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:420942] UBE2T [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6785341] Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA [LiteratureReference:6785350] Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection [LiteratureReference:6785352] FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL [LiteratureReference:6785355] UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination [LiteratureReference:421846] UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation [LiteratureReference:6785586] The genetic and biochemical basis of FANCD2 monoubiquitination [LiteratureReference:6786003] XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4
modified	[InstanceEdit:6785359] Orlic-Milacic, Marija, 2015-06-26 [InstanceEdit:6785379] Orlic-Milacic, Marija, 2015-06-26 [InstanceEdit:6785591] Orlic-Milacic, Marija, 2015-06-29 [InstanceEdit:6785595] Orlic-Milacic, Marija, 2015-06-29 [InstanceEdit:6785614] Orlic-Milacic, Marija, 2015-06-29 [InstanceEdit:6786004] Orlic-Milacic, Marija, 2015-07-02 [InstanceEdit:6788504] Orlic-Milacic, Marija, 2015-07-22 [InstanceEdit:6792506] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex
output	[Complex:6785340] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6785126] FA core complex assembles at DNA interstrand crosslinks (ICLs) [Homo sapiens] [Reaction:6785087] FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA [Homo sapiens] [BlackBoxEvent:6806425] TP53 stimulates FANCC expression [Homo sapiens] [Reaction:6785594] FANCD2 binds FANCI [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6792505] Fugger, Kasper, 2015-08-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796972] R-HSA-6785342.2
summation	[Summation:6785612] The ID2 complex, composed of FANCD2 and FANCI, binds to bran...
(hasEvent)	[Pathway:6783310] Fanconi Anemia Pathway [Homo sapiens]
(precedingEvent)	[Reaction:6788385] The complex of ATR and ATRIP is recruited to ICL-DNA [Homo sapiens]
(replacementInstances)	[_Deleted:6793254] Deletion of instance: 420781
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No pathways have been reviewed or authored by FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (6785342)