Query author contributions in Reactome
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Details on Person Tyrosine-449 (Y449) in the cytoplasmic domain of IL7ra is re...
| Class:Id | Summation:6785156 |
|---|---|
| _displayName | Tyrosine-449 (Y449) in the cytoplasmic domain of IL7ra is re... |
| _timestamp | 2015-06-25 13:47:59 |
| created | [InstanceEdit:6785154] Jupe, Steve, 2015-06-25 |
| literatureReference | [LiteratureReference:1264807] Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members [LiteratureReference:1264827] Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors [LiteratureReference:1264806] Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice |
| text | Tyrosine-449 (Y449) in the cytoplasmic domain of IL7ra is required for T-cell development in vivo and for activation of the Jak/Stat5 and PI3K/Akt pathways (Jiang et al. 2004, Pallard et al. 1999). It is thought that phosphorylated Y449 is a docking site for Stat5 (Pallard et al. 1999). T-cells from an Il7ra Y449F knock-in mouse did not activate Stat5 (Osbourne et al. 2007), indicating that Y449 is a key residue regulating IL7-mediated Stat5 activation. |
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No pathways have been reviewed or authored by Tyrosine-449 (Y449) in the cytoplasmic domain of IL7ra is re... (6785156)
