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Details on Person HSPG binds LPL dimer

Class:IdReaction:6784861
_displayNameHSPG binds LPL dimer
_doReleaseTRUE
_timestamp2017-02-16 16:15:44
authored[InstanceEdit:6784902] Sanchis, Alba, 2015-06-22
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:6784902] Sanchis, Alba, 2015-06-22
edited[InstanceEdit:8867484] Jassal, Bijay, 2016-04-12
input[SimpleEntity:1678620] HSPG [plasma membrane]
[Complex:174592] LPL dimer [extracellular region] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8867481] Interaction of lipoproteins with heparan sulfate proteoglycans and with lipoprotein lipase. Studies by surface plasmon resonance technique
[LiteratureReference:8867483] Heparan sulfate proteoglycans are primarily responsible for the maintenance of enzyme activity, binding, and degradation of lipoprotein lipase in Chinese hamster ovary cells
modified[InstanceEdit:8867480] Jassal, Bijay, 2016-04-14
[InstanceEdit:8868241] Jassal, Bijay, 2016-04-20
[InstanceEdit:8871222] Jassal, Bijay, 2016-05-13
[InstanceEdit:8871616] Weiser, JD
[InstanceEdit:8964195] D'Eustachio, Peter, 2017-02-15
[InstanceEdit:8964415] D'Eustachio, Peter, 2017-02-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameHSPG binds LPL dimer
output[Complex:8867477] HSPG:LPL dimer [plasma membrane] [Homo sapiens]
releaseDate2016-06-15
reviewed[InstanceEdit:8868240] D'Eustachio, Peter, 2016-04-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8873274] R-HSA-6784861.4
summation[Summation:8867479] LPL enzyme is catalytically active as a dimer composed of tw...
(hasEvent)[Pathway:8963889] Assembly of active LPL and LIPC lipase complexes [Homo sapiens]
(precedingEvent)[Reaction:6784628] PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer [Homo sapiens]
[Reaction:8857928] GPIHBP1 binds HSPG:LPL dimer [Homo sapiens]
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