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Details on Person The classical model of JAK-STAT signaling suggests that phos...

Class:IdSummation:6784802
_displayNameThe classical model of JAK-STAT signaling suggests that phos...
_timestamp2017-07-04 11:47:15
created[InstanceEdit:6784760] Jupe, Steve, 2015-06-22
literatureReference[LiteratureReference:1112553] Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
[LiteratureReference:2730550] STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3
[LiteratureReference:6784771] Canonical and non-canonical JAK-STAT signaling
[LiteratureReference:6785128] STATs get their move on
[LiteratureReference:6784754] Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography
modified[InstanceEdit:6784812] Jupe, Steve, 2015-06-22
[InstanceEdit:6785129] Jupe, Steve, 2015-06-25
[InstanceEdit:6785740] Jassal, Bijay, 2015-07-01
[InstanceEdit:6786759] Jupe, Steve, 2015-07-10
[InstanceEdit:8987651] Duenas, Corina, 2017-05-05
[InstanceEdit:9005492] Duenas, Corina, 2017-05-09
[InstanceEdit:9006065] Duenas, Corina, 2017-05-12
[InstanceEdit:9006703] Duenas, Corina, 2017-05-18
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009675] Duenas, Corina, 2017-06-22
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
[InstanceEdit:9011517] Duenas, Corina, 2017-07-03
[InstanceEdit:9011680] Jupe, Steve, 2017-07-04
textThe classical model of JAK-STAT signaling suggests that phosphorylated Signal transducer and activator of transcription 3 (STAT3) translocates to the nucleus (Akira et al. 1994) where it binds DNA to mediate the effects of Interleukin-10 (IL10) on expression of cytokines, soluble mediators and cell surface molecules by cells of myeloid origin, with important consequences for their ability to activate and sustain immune and inflammatory responses. STAT3 is able to shuttle freely between the cytoplasm and the nucleus, independent of tyrosine phosphorylation (Liu et al. 2005, Li 2008, Reich 2013). Binding of unphosphorylated STAT3 to DNA has been reported (Nkansah et al. 2013). As it is not clear what triggers nuclear accumulation of STAT3 in response to IL10 this event is shown as an uncertain process.
(summation)[BlackBoxEvent:6784763] p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm [Homo sapiens]
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