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Details on Person KEOPS complex [nucleoplasm]

Class:Id	Complex:6784495
_displayName	KEOPS complex [nucleoplasm]
_timestamp	2025-02-16 23:15:24
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6784449] May, Bruce, 2015-06-20
hasComponent	[EntityWithAccessionedSequence:6784525] LAGE3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6784525] LAGE3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6784522] OSGEP [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6784522] OSGEP [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6784489] TP53RK [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6784489] TP53RK [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6784505] TPRKB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6784505] TPRKB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9938502] C14orf142 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9938502] C14orf142 [nucleoplasm] [Homo sapiens]
inferredFrom	[Complex:6784450] KEOPS complex [nucleoplasm] [Saccharomyces cerevisiae]
isChimeric	FALSE
literatureReference	[LiteratureReference:6784491] The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME [LiteratureReference:9938482] Defects in t⁶A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome
modified	[InstanceEdit:6785394] May, Bruce, 2015-06-27 [InstanceEdit:9938509] May, Bruce, 2025-02-16
name	KEOPS complex
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6795347] R-HSA-6784495.2
(physicalEntity)	[CatalystActivity:6784452] tRNA N(6)-L-threonylcarbamoyladenine synthase activity of KEOPS complex [nucleoplasm]
(updatedInstance)	[_UpdateTracker:9940048] Update Tracker - [Complex:6784495] KEOPS complex [nucleoplasm] - v92:[modifyName, removeHasComponent, removeLiteratureReference]
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No pathways have been reviewed or authored by KEOPS complex [nucleoplasm] (6784495)