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Details on Person ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate

Class:Id	Reaction:6784402
_displayName	ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate
_doRelease	TRUE
_timestamp	2025-02-25 22:16:21
authored	[InstanceEdit:6784221] D'Eustachio, Peter, 2015-06-18
catalystActivity	[CatalystActivity:70678] L-glutamate gamma-semialdehyde dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643321] 1-pyrroline-5-carboxylate dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix] Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6784426] D'Eustachio, Peter, 2015-06-19
crossReference	[DatabaseIdentifier:9929457] RHEA:31156
edited	[InstanceEdit:6784221] D'Eustachio, Peter, 2015-06-18
goBiologicalProcess	[GO_BiologicalProcess:15010] glyoxylate metabolic process
input	[SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:9929425] 1PYR-3OH-5COOH [mitochondrial matrix] [SimpleEntity:113526] NAD+ [mitochondrial matrix]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:389852] Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta 1-pyrroline-3-hydroxy-5-carboxylate [LiteratureReference:6784417] The three-dimensional structural basis of type II hyperprolinemia [LiteratureReference:389804] Genetic evidence for a common enzyme catalyzing the second step in the degradation of proline and hydroxyproline
modified	[InstanceEdit:6784427] D'Eustachio, Peter, 2015-06-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8949530] D'Eustachio, Peter, 2016-11-25 [InstanceEdit:8953407] D'Eustachio, Peter, 2016-12-22 [InstanceEdit:8953519] D'Eustachio, Peter, 2016-12-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH
output	[SimpleEntity:9929459] 4OH-L-Glu [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:6784224] PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate [Homo sapiens] [BlackBoxEvent:6784213] Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2017-03-27
reviewed	[InstanceEdit:8953518] Jassal, Bijay, 2016-12-23 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8929915] R-HSA-6784402.3
structureModified	[InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04
summation	[Summation:6784391] Mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenase ...
(hasEvent)	[Pathway:389661] Glyoxylate metabolism and glycine degradation [Homo sapiens]
(precedingEvent)	[Reaction:6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) [Homo sapiens]
(replacementInstances)	[_Deleted:6784428] Deletion of instance: 389859 [_Deleted:9930638] Deletion of instance: 6784399
(updatedInstance)	[_UpdateTracker:9939799] Update Tracker - [Reaction:6784402] ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate - v92:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText, removeCatalystActivity]
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