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Details on Person IL10 negatively regulates extracellular inflammatory mediators
Class:Id BlackBoxEvent:6784160 _displayName IL10 negatively regulates extracellular inflammatory mediators _doRelease TRUE _timestamp 2016-11-14 13:49:38 authored [InstanceEdit:6783726] Jupe, Steve, 2015-06-17 compartment [Compartment:984] extracellular region [Compartment:7660] nucleoplasm created [InstanceEdit:6784035] Jupe, Steve, 2015-06-18 edited [InstanceEdit:8948388] Jupe, Steve, 2016-11-14 input [DefinedSet:6784990] IL10-downregulated genes for extracellular proteins [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:6783764] Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes [LiteratureReference:6784109] Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10 [LiteratureReference:6783755] IL-10 inhibits cytokine production by activated macrophages [LiteratureReference:6783791] Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells [LiteratureReference:6784056] Macrophage-colony-stimulating factor expression by anti-CD45 stimulated human monocytes is transcriptionally up-regulated by IL-1 beta and inhibited by IL-4 and IL-10 [LiteratureReference:6784077] Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages [LiteratureReference:6784086] Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta [LiteratureReference:6784033] Contrasting effects of IL-4, IL-10 and corticosteroids on RANTES production by human monocytes [LiteratureReference:6784128] Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo [LiteratureReference:6784101] The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils [LiteratureReference:6784093] IFN-gamma and IL-10 inhibit induction of IL-1 receptor type I and type II gene expression by IL-4 and IL-13 in human monocytes modified [InstanceEdit:6784179] Jupe, Steve, 2015-06-18 [InstanceEdit:6784760] Jupe, Steve, 2015-06-22 [InstanceEdit:6784998] Jupe, Steve, 2015-06-23 [InstanceEdit:6785040] Jupe, Steve, 2015-06-24 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933245] Jupe, Steve, 2016-08-04 [InstanceEdit:8934460] Jupe, Steve, 2016-08-09 [InstanceEdit:8937646] Jupe, Steve, 2016-09-05 [InstanceEdit:8937650] Jupe, Steve, 2016-09-06 [InstanceEdit:8948394] Jupe, Steve, 2016-11-14 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name IL10 negatively regulates extracellular inflammatory mediators output [DefinedSet:6784987] IL10-downregulated extracellular proteins [extracellular region] [Homo sapiens] precedingEvent
regulatedBy [NegativeGeneExpressionRegulation:6785079] Negative gene expression regulation by 'IL10 [extracellular region]' releaseDate 2016-12-12 reviewed [InstanceEdit:8937647] Meldal, Birgit, 2016-09-05 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:8892364] R-HSA-6784160.3 summation [Summation:6784138] IL10 modulates the expression of cytokines, soluble mediator... (hasEvent) [Pathway:6783783] Interleukin-10 signaling [Homo sapiens]
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