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Details on Person STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2

Class:Id	Reaction:6784006
_displayName	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
_doRelease	TRUE
_timestamp	2016-11-14 13:50:21
authored	[InstanceEdit:6783726] Jupe, Steve, 2015-06-17
catalystActivity	[CatalystActivity:6784801] protein tyrosine kinase activity of IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:6784035] Jupe, Steve, 2015-06-18
edited	[InstanceEdit:8948388] Jupe, Steve, 2016-11-14
input	[Complex:6784795] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6784788] Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
modified	[InstanceEdit:6784179] Jupe, Steve, 2015-06-18 [InstanceEdit:6784760] Jupe, Steve, 2015-06-22 [InstanceEdit:6785129] Jupe, Steve, 2015-06-25 [InstanceEdit:6785911] Jupe, Steve, 2015-07-01 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933245] Jupe, Steve, 2016-08-04 [InstanceEdit:8934460] Jupe, Steve, 2016-08-09 [InstanceEdit:8937646] Jupe, Steve, 2016-09-05 [InstanceEdit:8948394] Jupe, Steve, 2016-11-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 phosphorylates IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3
output	[Complex:6784779] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 [Homo sapiens] [BlackBoxEvent:6784324] p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA [Homo sapiens]
releaseDate	2016-12-12
reviewed	[InstanceEdit:8937647] Meldal, Birgit, 2016-09-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8917539] R-HSA-6784006.2
summation	[Summation:6784031] STAT3 bound to IL10RA is tyrosine phosphorylated by the rece...
(hasEvent)	[Pathway:6783783] Interleukin-10 signaling [Homo sapiens]
(precedingEvent)	[Reaction:6784791] p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [Homo sapiens]
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No pathways have been reviewed or authored by STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (6784006)