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Details on Person PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

Class:Id	Reaction:6783939
_displayName	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
_doRelease	TRUE
_timestamp	2024-11-08 15:23:00
authored	[InstanceEdit:6783946] D'Eustachio, Peter, 2015-06-17
catalystActivity	[CatalystActivity:6783944] pyrroline-5-carboxylate reductase activity of PYCR2 decamer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643784] pyrroline-5-carboxylate reductase activity of PYCR2 decamer [mitochondrial matrix] Functional specialization in proline biosynthesis of melanoma
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6783946] D'Eustachio, Peter, 2015-06-17
crossReference	[DatabaseIdentifier:9925796] RHEA:14111
edited	[InstanceEdit:6783946] D'Eustachio, Peter, 2015-06-17
input	[SimpleEntity:35305] 1PYR-5COOH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol]
internalReviewed	[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
literatureReference	[LiteratureReference:6783923] Functional specialization in proline biosynthesis of melanoma [LiteratureReference:70647] Crystal structure of human recombinant ornithine aminotransferase. [LiteratureReference:70657] Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. [LiteratureReference:6783947] Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination
modified	[InstanceEdit:6793056] D'Eustachio, Peter, 2015-08-28 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 [InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31 [InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
name	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro 1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)
output	[SimpleEntity:113538] L-Pro [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate [Homo sapiens] [Reaction:70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Homo sapiens] [Reaction:508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790586] Jassal, Bijay, 2015-08-13 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796961] R-HSA-6783939.4
structureModified	[InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
summation	[Summation:6783949] Pyrroline-5-carboxylate reductase 2 (PYCR2) catalyzes the re...
(hasEvent)	[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9928453] Update Tracker - [Reaction:6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v91:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
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