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Query author contributions in Reactome

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Details on Person Members of the interleukin-6 (IL-6) cytokines, IL-6, IL-11, ...

Class:IdSummation:6783696
_displayNameMembers of the interleukin-6 (IL-6) cytokines, IL-6, IL-11, ...
_timestamp2015-06-16 13:26:25
created[InstanceEdit:6783691] Garapati, Phani Vijay, 2015-06-16
literatureReference[LiteratureReference:6783565] Gp130 and the interleukin-6 family of cytokines
[LiteratureReference:6783587] Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders
textMembers of the interleukin-6 (IL-6) cytokines, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM) cardiotrophin-1 (CT-1) and cardiotrophin-like cytokine (CLC) share one or both of the receptor signal transducing subunits glycoprotein (gp) 130 and LIFR in their respective receptor complexes (Taga et al. 1997). gp130 (also known as CD130) is the central signal transducer of the interleukin-6 (IL6)-related cytokines. It is expressed in almost all organs, including heart, kidney, spleen, liver, lung, placenta, and brain. Mice lacking gp130 gene results in embryonic lethality at day 12.5 (Yoshida et al. 1996). CNTFR alpha bound to CNTFR or CLCF1:CRLF1 complex recruits gp130 by binding to the cytokine-binding domain (CBD) of gp130 (Man et al. 2003).
(summation)[Reaction:6783530] gp130:JAKs bind CNTFR [Homo sapiens]
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No pathways have been reviewed or authored by Members of the interleukin-6 (IL-6) cytokines, IL-6, IL-11, ... (6783696)
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