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Details on Person LIFR:JAKs bind gp130:JAKs:CNTFR

Class:IdReaction:6783556
_displayNameLIFR:JAKs bind gp130:JAKs:CNTFR
_doReleaseTRUE
_timestamp2015-11-20 15:10:20
authored[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:6783691] Garapati, Phani Vijay, 2015-06-16
edited[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21
input[Complex:6783658] CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] [Homo sapiens]
[Complex:6784198] JAKs:LIFR [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:6783600] LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor
[LiteratureReference:6783522] Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro
[LiteratureReference:6783693] Expression of leukaemia inhibitory factor receptor subunits LIFR beta and gp130 in human oocytes and preimplantation embryos
[LiteratureReference:6783660] The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling
modified[InstanceEdit:6784209] Garapati, Phani Vijay, 2015-06-18
[InstanceEdit:6784377] Garapati, Phani Vijay, 2015-06-19
[InstanceEdit:6788468] Garapati, Phani Vijay, 2015-07-21
[InstanceEdit:6809137] Garapati, Phani Vijay, 2015-11-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLIFR:JAKs bind gp130:JAKs:CNTFR
output[Complex:6783544] CNTF:CNTFR,CRLF1:CLCF1:CNTFR:gp130:JAKs:LIFR:JAKs [plasma membrane] [Homo sapiens]
releaseDate2015-12-15
releaseStatusNEW
reviewed[InstanceEdit:6809153] Narazaki, M, Tanaka, M, 2015-11-09
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6812428] R-HSA-6783556.2
summation[Summation:6783602] The cytokine receptor gp130 is the shared signalling subunit...
(hasEvent)[Pathway:6788467] IL-6-type cytokine receptor ligand interactions [Homo sapiens]
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No pathways have been reviewed or authored by LIFR:JAKs bind gp130:JAKs:CNTFR (6783556)