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Details on Person Cardiotrophin-like cytokine factor 1 (CLCF1 also referred as...
| Class:Id | Summation:6783527 |
|---|---|
| _displayName | Cardiotrophin-like cytokine factor 1 (CLCF1 also referred as... |
| _timestamp | 2015-07-21 11:04:34 |
| created | [InstanceEdit:6783691] Garapati, Phani Vijay, 2015-06-16 |
| modified | [InstanceEdit:6788469] Garapati, Phani Vijay, 2015-07-21 |
| text | Cardiotrophin-like cytokine factor 1 (CLCF1 also referred as NNT1 or BSF3) binds to the tripartite CNTFR complex and activates Jak-STAT, MAPK and PI3/Akt signaling pathways in various cell systems. Function of CLCF1 includes neurotrophic and B cell stimulatory effects, as well as neuroimmunoendocrine modulation of corticotroph function. Cellular secretion of CLCF1 requires heteromeric complex formation with other IL-6 family member cytokine receptor-like factor 1 (CRLF1 also called CLF1). It is a secreted receptor belonging to the interleukin-6 family of cytokines. This heteromeric CRLF1:CLCF1 is a stable sectreted complex that acts as a second ligand for ciliary neurotrophic factor receptor (CNTFR) tripartite receptor complex (Elson et al. 2000, Vlotides et al. 2004). |
| (summation) | [Reaction:6783670] CRLF1 binds CLCF1 [Homo sapiens] |
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No pathways have been reviewed or authored by Cardiotrophin-like cytokine factor 1 (CLCF1 also referred as... (6783527)
