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Details on Person TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)

Class:Id	Reaction:6783455
_displayName	TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)
_doRelease	TRUE
_timestamp	2015-10-24 03:47:55
authored	[InstanceEdit:6783442] May, Bruce, 2015-06-15
catalystActivity	[CatalystActivity:6783464] 2-oxoglutarate-dependent dioxygenase activity of TYW5:Fe2+ dimer [cytoplasm]
catalystActivityReference	[CatalystActivityReference:9643846] 2-oxoglutarate-dependent dioxygenase activity of TYW5:Fe2+ dimer [cytoplasm] Expanding role of the jumonji C domain as an RNA hydroxylase
compartment	[Compartment:459] cytoplasm
created	[InstanceEdit:6783459] May, Bruce, 2015-06-15
edited	[InstanceEdit:6783442] May, Bruce, 2015-06-15
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
input	[GenomeEncodedEntity:6782871] tRNA(Phe) containing yW-72 at 37 [cytoplasm] [Homo sapiens] [SimpleEntity:5278317] 2OG [cytoplasm] [SimpleEntity:1131511] O2 [cytoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6783503] Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification [LiteratureReference:6783481] Expanding role of the jumonji C domain as an RNA hydroxylase
modified	[InstanceEdit:6784528] May, Bruce, 2015-06-20 [InstanceEdit:6785439] May, Bruce, 2015-06-27 [InstanceEdit:6785440] May, Bruce, 2015-06-27 [InstanceEdit:6785482] May, Bruce, 2015-06-28 [InstanceEdit:6792692] May, Bruce, 2015-08-25 [InstanceEdit:6806694] May, Bruce, 2015-10-24 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)
output	[GenomeEncodedEntity:6783496] tRNA(Phe) containing OHyW-72 at 37 [cytoplasm] [Homo sapiens] [SimpleEntity:1132345] CO2 [cytoplasm] [SimpleEntity:5278787] SUCCA [cytoplasm]
precedingEvent	[Reaction:6782879] TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) [Homo sapiens] [Reaction:6782893] TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796956] R-HSA-6783455.4
summation	[Summation:6785397] TYW5 uses 2-oxoglutarate and molecular oxygen to hydroxylate...
(hasEvent)	[Pathway:6782861] Synthesis of wybutosine at G37 of tRNA(Phe) [Homo sapiens]
(precedingEvent)	[Reaction:6783473] LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe) [Homo sapiens]
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