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Details on Person HAGH hydrolyses (R)-S-LGSH to GSH and LACT

Class:Id	Reaction:6783221
_displayName	HAGH hydrolyses (R)-S-LGSH to GSH and LACT
_doRelease	TRUE
_timestamp	2026-01-08 13:55:26
authored	[InstanceEdit:6783212] Jassal, Bijay, 2015-06-11
catalystActivity	[CatalystActivity:6783215] hydroxyacylglutathione hydrolase activity of HAGH-2:2xZn2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6783212] Jassal, Bijay, 2015-06-11
crossReference	[DatabaseIdentifier:9861799] RHEA:25246
edited	[InstanceEdit:6783212] Jassal, Bijay, 2015-06-11
goBiologicalProcess	[GO_BiologicalProcess:172230] methylglyoxal catabolic process
input	[SimpleEntity:5694130] (R)-S-LGSH [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9862077] D'Eustachio, Peter, 2024-02-22
isChimeric	FALSE
literatureReference	[LiteratureReference:6783213] Molecular cloning, heterologous expression, and characterization of human glyoxalase II [LiteratureReference:6783220] The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II [LiteratureReference:6783209] Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue
modified	[InstanceEdit:6784944] Jassal, Bijay, 2015-06-23 [InstanceEdit:6785227] Jassal, Bijay, 2015-06-25 [InstanceEdit:6785238] Jassal, Bijay, 2015-06-26 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6787801] Jassal, Bijay, 2015-07-17 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861803] Stephan, Ralf, 2024-02-21 [InstanceEdit:9861989] Stephan, Ralf, 2024-02-22 [InstanceEdit:9862078] D'Eustachio, Peter, 2024-02-22 [InstanceEdit:9862099] D'Eustachio, Peter, 2024-02-22 [InstanceEdit:9863123] Stephan, Ralf, 2024-02-27 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 [InstanceEdit:9978814] D'Eustachio, Peter, 2026-01-08
name	HAGH hydrolyses (R)-S-LGSH to GSH and LACT
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:5279872] D-LACT [cytosol] [SimpleEntity:2564757] (2Fe-2S)(1+) [cytosol]
precedingEvent	[Reaction:5694071] GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9862100] Matthews, Lisa, 2024-02-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796949] R-HSA-6783221.5
structureModified	[InstanceEdit:9861803] Stephan, Ralf, 2024-02-21
summation	[Summation:6783216] In the second step of the glyoxalase system, hydroxyacylglut...
(hasEvent)	[Pathway:70268] Pyruvate metabolism [Homo sapiens] [Pathway:9861990] Methylglyoxal degradation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864129] Update Tracker - [Reaction:6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT - v88:[addInput, add_removeOutput, modifyText]
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