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Details on Person Though not required for normal development (Pannu et al. 201...
| Class:Id | Summation:6783168 |
|---|---|
| _displayName | Though not required for normal development (Pannu et al. 201... |
| _timestamp | 2016-02-09 15:44:49 |
| created | [InstanceEdit:6783058] Jupe, Steve, 2015-06-10 |
| literatureReference | [LiteratureReference:5690174] Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation [LiteratureReference:5690195] Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 [LiteratureReference:5690311] The interleukin-1 family: back to the future [LiteratureReference:5690301] Nuclear IL-33 is a transcriptional regulator of NF-?B p65 and induces endothelial cell activation [LiteratureReference:5690135] Deubiquitination and stabilization of IL-33 by USP21 |
| modified | [InstanceEdit:6783203] Jupe, Steve, 2015-06-10 [InstanceEdit:8856270] Jupe, Steve, 2016-02-09 |
| text | Though not required for normal development (Pannu et al. 2015), USP21 is essential in innate and adaptive immune responses (Tao et al. 2014). It deubiquitinates the Th2 specific transcription factor GATA3. This positive regulation is important for the function of regulatory T cells (Zhang et al. 2013). USP21 also deubiquitinates IL-33, which is both a cytokine and a chromatin-associated nuclear protein known as Nuclear factor from high endothelial venule (NF-HEV), which is associated with many inflammatory diseases (Garlanda et al. 2013). IL-33 can bind to the RELA (NFkB p65) promoter region, inducing endothelial cell activation (Choi et al. 2012). Depletion of USP21 reduces IL-33 protein levels and IL-33-mediated RELA promoter activity (Tao et al. 2014). |
| (summation) | [Reaction:6783177] USP21 deubiquitinates GATA3,IL33 [Homo sapiens] |
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No pathways have been reviewed or authored by Though not required for normal development (Pannu et al. 201... (6783168)
