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Details on Person EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5

Class:Id	BlackBoxEvent:6782685
_displayName	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5
_doRelease	TRUE
_timestamp	2016-03-03 21:09:24
authored	[InstanceEdit:6782689] Jassal, Bijay, 2015-06-08
catalystActivity	[CatalystActivity:6782688] mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of EDEM1,3 [endoplasmic reticulum quality control compartment]
compartment	[Compartment:927893] endoplasmic reticulum quality control compartment
created	[InstanceEdit:6782689] Jassal, Bijay, 2015-06-08
edited	[InstanceEdit:6782689] Jassal, Bijay, 2015-06-08
goBiologicalProcess	[GO_BiologicalProcess:6792153] mannose trimming involved in glycoprotein ERAD pathway
input	[Complex:912284] unfolded protein:(GlcNAc)2 (Man)8b [endoplasmic reticulum quality control compartment] [Homo sapiens] [SimpleEntity:6781870] H2O [endoplasmic reticulum quality control compartment] [SimpleEntity:6781870] H2O [endoplasmic reticulum quality control compartment] [SimpleEntity:6781870] H2O [endoplasmic reticulum quality control compartment]
isChimeric	FALSE
literatureReference	[LiteratureReference:6782579] EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step [LiteratureReference:901022] EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming
modified	[InstanceEdit:6782713] Jassal, Bijay, 2015-06-08 [InstanceEdit:6784607] Jassal, Bijay, 2015-06-22 [InstanceEdit:6793492] Jassal, Bijay, 2015-09-01 [InstanceEdit:6793639] Matthews, Lisa, 2015-09-02 [InstanceEdit:8855765] Jassal, Bijay, 2016-02-05 [InstanceEdit:8863066] Weiser, JD, 2016-03-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5
output	[Complex:6782692] unfolded protein:(GlcNAc)2 (Man)5 [endoplasmic reticulum quality control compartment] [Homo sapiens] [SimpleEntity:912281] Man [endoplasmic reticulum quality control compartment] [SimpleEntity:912281] Man [endoplasmic reticulum quality control compartment] [SimpleEntity:912281] Man [endoplasmic reticulum quality control compartment]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6784606] Dall'Olio, Giovanni, 2015-06-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797040] R-HSA-6782685.4
summation	[Summation:6782687] Proteins with major folding defects are extracted from futil...
(hasEvent)	[Pathway:901032] ER Quality Control Compartment (ERQC) [Homo sapiens]
(precedingEvent)	[Reaction:8867288] OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 [Homo sapiens]
(replacementInstances)	[_Deleted:8855770] Deletion of instance: 1018376
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No pathways have been reviewed or authored by EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 (6782685)