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Details on Person QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr)

Class:Id	Reaction:6782443
_displayName	QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr)
_doRelease	TRUE
_timestamp	2025-06-02 14:49:30
authored	[InstanceEdit:6782392] May, Bruce, 2015-06-07
catalystActivity	[CatalystActivity:6782432] tRNA-guanosine(34) queuine transglycosylase activity of QTRT1:QTRTD1 [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9643759] queuine tRNA-ribosyltransferase activity of QTRT1:QTRTD1 [mitochondrial outer membrane] Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:6782426] May, Bruce, 2015-06-08
edited	[InstanceEdit:6782392] May, Bruce, 2015-06-07
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
input	[SimpleEntity:6782431] queuine [cytosol] [DefinedSet:9942526] tRNA(Asn),(Asp),(His),(Tyr) containing G-34 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6782460] Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure [LiteratureReference:6785419] Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases [LiteratureReference:6782413] Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase
modified	[InstanceEdit:6784528] May, Bruce, 2015-06-20 [InstanceEdit:6785439] May, Bruce, 2015-06-27 [InstanceEdit:6788634] May, Bruce, 2015-07-23 [InstanceEdit:6792692] May, Bruce, 2015-08-25 [InstanceEdit:6806694] May, Bruce, 2015-10-24 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9942320] May, Bruce, 2025-03-14 [InstanceEdit:9942540] May, Bruce, 2025-03-17 [InstanceEdit:9953423] May, Bruce, 2025-06-02
name	QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr)
output	[SimpleEntity:83956] Gua [cytosol] [DefinedSet:9942522] tRNA(Asn),(Asp),(His),(Tyr) containing Q-34 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:6783483] tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol [Homo sapiens] [Reaction:6785478] Processed tRNA binds XPOT and RAN:GTP [Homo sapiens] [Reaction:9942295] QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24 [InstanceEdit:9942529] Swairjo, Manal A, 2025-03-17 [InstanceEdit:9953420] May, Bruce, 2025-06-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796941] R-HSA-6782443.5
structureModified	[InstanceEdit:9942540] May, Bruce, 2025-03-17
summation	[Summation:6785435] The transglycosylase complex QTRT1:QTRTD1 exchanges guanine ...
(hasEvent)	[Pathway:6782315] tRNA modification in the nucleus and cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9953640] Update Tracker - [Reaction:6782443] QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) - v93:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) (6782443)