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Details on Person THG1L transfers GMP to 5' end of tRNA(His)

Class:Id	Reaction:6782434
_displayName	THG1L transfers GMP to 5' end of tRNA(His)
_doRelease	TRUE
_timestamp	2018-11-20 04:01:31
authored	[InstanceEdit:6782392] May, Bruce, 2015-06-07
catalystActivity	[CatalystActivity:6782459] nucleotidyltransferase activity of THG1L [cytosol]
catalystActivityReference	[CatalystActivityReference:9643429] nucleotidyltransferase activity of THG1L [cytosol] tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6782426] May, Bruce, 2015-06-08
edited	[InstanceEdit:6782392] May, Bruce, 2015-06-07
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
input	[GenomeEncodedEntity:379758] tRNA(His) [cytosol] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6782396] tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases
modified	[InstanceEdit:6785439] May, Bruce, 2015-06-27 [InstanceEdit:6785482] May, Bruce, 2015-06-28 [InstanceEdit:6787709] May, Bruce, 2015-07-15 [InstanceEdit:6788634] May, Bruce, 2015-07-23 [InstanceEdit:6792692] May, Bruce, 2015-08-25 [InstanceEdit:6806694] May, Bruce, 2015-10-24 [InstanceEdit:9629284] May, Bruce, 2018-11-20 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	THG1L transfers GMP to 5' end of tRNA(His)
output	[GenomeEncodedEntity:6782455] 5'-pppG-p-tRNA(His) [cytosol] [Homo sapiens] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:6783483] tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol [Homo sapiens] [Reaction:6785478] Processed tRNA binds XPOT and RAN:GTP [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796940] R-HSA-6782434.5
summation	[Summation:6785398] THG1L (THG1) adds a guanosine triphosphate residue to the 5'...
(hasEvent)	[Pathway:6782315] tRNA modification in the nucleus and cytosol [Homo sapiens]
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