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Details on Person DUS2:EPRS reduces uridine to dihydrouridine in tRNAs

Class:Id	Reaction:6782296
_displayName	DUS2:EPRS reduces uridine to dihydrouridine in tRNAs
_doRelease	TRUE
_timestamp	2015-10-24 03:30:05
authored	[InstanceEdit:5696820] May, Bruce, 2015-05-30
catalystActivity	[CatalystActivity:6782306] tRNA dihydrouridine synthase activity of DUS2:EPRS [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6782319] May, Bruce, 2015-06-06
edited	[InstanceEdit:5696820] May, Bruce, 2015-05-30
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
inferredFrom	[Reaction:6790127] SMM1 (DUS2) reduces uridine-20 to dihydrouridine in tRNA(Leu) [Saccharomyces cerevisiae]
input	[GenomeEncodedEntity:6782279] tRNA containing U [cytosol] [Homo sapiens] [DefinedSet:428206] NAD(P)H [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6782335] A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis
modified	[InstanceEdit:6784528] May, Bruce, 2015-06-20 [InstanceEdit:6785394] May, Bruce, 2015-06-27 [InstanceEdit:6788634] May, Bruce, 2015-07-23 [InstanceEdit:6790222] May, Bruce, 2015-08-09 [InstanceEdit:6792692] May, Bruce, 2015-08-25 [InstanceEdit:6806694] May, Bruce, 2015-10-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DUS2:EPRS reduces uridine to dihydrouridine in tRNAs
output	[GenomeEncodedEntity:6782353] tRNA containing dihydroU [cytosol] [Homo sapiens] [DefinedSet:428218] NAD(P)+ [cytosol]
precedingEvent	[Reaction:6783483] tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol [Homo sapiens] [Reaction:6785478] Processed tRNA binds XPOT and RAN:GTP [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796933] R-HSA-6782296.3
summation	[Summation:6785389] DUS2 catalyzes the reduction of the 5,6 double bond in uridi...
(hasEvent)	[Pathway:6782315] tRNA modification in the nucleus and cytosol [Homo sapiens]
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No pathways have been reviewed or authored by DUS2:EPRS reduces uridine to dihydrouridine in tRNAs (6782296)