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Details on Person 3' incision by ERCC5 (XPG) in TC-NER

Class:Id	Reaction:6782224
_displayName	3' incision by ERCC5 (XPG) in TC-NER
_doRelease	TRUE
_timestamp	2022-09-13 18:03:20
authored	[InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity	[CatalystActivity:6782216] DNA endonuclease activity of TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782207] Orlic-Milacic, Marija, 2015-06-05
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
input	[Complex:6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5690036] Coordination of dual incision and repair synthesis in human nucleotide excision repair [LiteratureReference:5690482] Replication protein A safeguards genome integrity by controlling NER incision events
modified	[InstanceEdit:6782226] Orlic-Milacic, Marija, 2015-06-05 [InstanceEdit:6783797] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6792501] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792503] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9816782] Orlic-Milacic, Marija, 2022-09-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3' incision by ERCC5 (XPG) in TC-NER
output	[Complex:109943] ERCC1:ERCC4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:67447] ERCC5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] [Homo sapiens] [Complex:6782222] TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6782211] DNA polymerases delta, epsilon or kappa bind the TC-NER site [Homo sapiens] [Reaction:6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796929] R-HSA-6782224.3
summation	[Summation:6782225] In transcription-coupled nucleotide excision repair (TC-NER)...
(hasEvent)	[Pathway:6782135] Dual incision in TC-NER [Homo sapiens]
(precedingEvent)	[Reaction:6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER [Homo sapiens]
(replacementInstances)	[_Deleted:6793183] Deletion of instance: 109975
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No pathways have been reviewed or authored by 3' incision by ERCC5 (XPG) in TC-NER (6782224)