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Details on Person ERCC5 and RPA bind TC-NER site
Class:Id Reaction:6782138
_displayName ERCC5 and RPA bind TC-NER site
_doRelease TRUE
_timestamp 2015-09-04 20:36:13
authored [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:6782136] Orlic-Milacic, Marija, 2015-06-04
edited [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
input [Complex:6782111] TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] [Homo sapiens] [Complex:68462] RPA heterotrimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:67447] ERCC5 [nucleoplasm] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:6782132] Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome [LiteratureReference:6782126] UvrD facilitates DNA repair by pulling RNA polymerase backwards [LiteratureReference:5689499] DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair [LiteratureReference:5689231] RPA involvement in the damage-recognition and incision steps of nucleotide excision repair [LiteratureReference:5689235] Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA [LiteratureReference:5689511] The spacer region of XPG mediates recruitment to nucleotide excision repair complexes and determines substrate specificity [LiteratureReference:5689523] Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH [LiteratureReference:5689525] XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients
modified [InstanceEdit:6783797] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6792501] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792503] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name ERCC5 and RPA bind TC-NER site
output [Complex:6782134] TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate 2004-03-06
reviewed [InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
reviewStatus [ReviewStatus:9821382] five stars
revised [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:6796924] R-HSA-6782138.2
summation [Summation:6782137] It has been suggested that, similar to the UvrD helicase inv...
(hasEvent) [Pathway:6782135] Dual incision in TC-NER [Homo sapiens]
(precedingEvent) [Reaction:6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER [Homo sapiens]
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No pathways have been reviewed or authored by ERCC5 and RPA bind TC-NER site (6782138)