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Details on Person ERCC2-facilitated RNA Pol II backtracking in TC-NER
Class:Id Reaction:6782131
_displayName ERCC2-facilitated RNA Pol II backtracking in TC-NER
_doRelease TRUE
_timestamp 2020-04-20 21:34:18
authored [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity [CatalystActivity:6782120] 5'-3' DNA helicase activity of TC-NER pre-incision complex [nucleoplasm]
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:6782121] Orlic-Milacic, Marija, 2015-06-04
edited [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
input [Complex:6782066] TC-NER pre-incision complex [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric FALSE
literatureReference [LiteratureReference:6782132] Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome [LiteratureReference:6782126] UvrD facilitates DNA repair by pulling RNA polymerase backwards [LiteratureReference:5689311] Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair [LiteratureReference:5689302] Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation [LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template
modified [InstanceEdit:6782206] Orlic-Milacic, Marija, 2015-06-05 [InstanceEdit:6783709] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:6783797] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6783799] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6792501] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792503] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9684130] Orlic-Milacic, Marija, 2020-04-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name ERCC2-facilitated RNA Pol II backtracking in TC-NER
output [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113550] Pi [nucleoplasm] [Complex:9684117] TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate 2004-03-06
reviewed [InstanceEdit:6790576] Fousteri, Maria, 2015-08-03 [InstanceEdit:9684094] D'Eustachio, Peter, 2020-04-20
reviewStatus [ReviewStatus:9821382] five stars
revised [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:9684048] Orlic-Milacic, Marija, 2020-04-20
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:6796923] R-HSA-6782131.3
summation [Summation:6782118] The DNA helicase XPD (ERCC2), which is part of the TFIIH com...
(hasEvent) [Pathway:6782135] Dual incision in TC-NER [Homo sapiens]
(precedingEvent) [Reaction:6782138] ERCC5 and RPA bind TC-NER site [Homo sapiens] [Reaction:9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER [Homo sapiens]
(replacementInstances) [_Deleted:6793202] Deletion of instance: 109974
(updatedInstance) [_UpdateTracker:9777032] Update Tracker - [Reaction:6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - v73:[add_removeOutput, modifyText]
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