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Details on Person UVSSA:USP7 deubiquitinates ERCC6

Class:Id	Reaction:6782069
_displayName	UVSSA:USP7 deubiquitinates ERCC6
_doRelease	TRUE
_timestamp	2015-09-04 20:36:11
authored	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity	[CatalystActivity:6782064] cysteine-type deubiquitinase activity of Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782070] Orlic-Milacic, Marija, 2015-06-04
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
input	[Complex:6782063] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] [Homo sapiens] [SimpleEntity:113518] H2O [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6781981] Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair [LiteratureReference:6781971] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair [LiteratureReference:6781993] UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair [LiteratureReference:6782030] KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR)
modified	[InstanceEdit:6783709] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:6783799] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6792501] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792503] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792919] Orlic-Milacic, Marija, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	UVSSA:USP7 deubiquitinates ERCC6
output	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [Complex:6782066] TC-NER pre-incision complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6782004] Assembly of the pre-incision complex in TC-NER [Homo sapiens] [Reaction:6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796922] R-HSA-6782069.2
summation	[Summation:6782067] UVSSA stabilizes ERCC6 (CSB) during transcription-coupled nu...
(hasEvent)	[Pathway:6781823] Formation of TC-NER Pre-Incision Complex [Homo sapiens]
(precedingEvent)	[Reaction:6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER [Homo sapiens]
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No pathways have been reviewed or authored by UVSSA:USP7 deubiquitinates ERCC6 (6782069)