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Details on Person Assembly of the pre-incision complex in TC-NER

Class:Id	Reaction:6782004
_displayName	Assembly of the pre-incision complex in TC-NER
_doRelease	TRUE
_timestamp	2024-02-22 21:28:05
authored	[InstanceEdit:110274] Gopinathrao, G, 2004-01-29 18:08:32 [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6781974] Orlic-Milacic, Marija, 2015-06-03
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:9862096] Orlic-Milacic, Marija, 2024-02-22
input	[Complex:6781866] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Homo sapiens] [Complex:6781845] UVSSA:USP7 [nucleoplasm] [Homo sapiens] [Complex:6781957] XAB2 complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:65748] TCEA1 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9862078] D'Eustachio, Peter, 2024-02-22
isChimeric	FALSE
literatureReference	[LiteratureReference:6781991] XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription [LiteratureReference:6781965] Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair [LiteratureReference:5689620] Nucleotide excision repair driven by the dissociation of CAK from TFIIH [LiteratureReference:6781971] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair [LiteratureReference:6781993] UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair [LiteratureReference:6782030] KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR) [LiteratureReference:6781996] Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability [LiteratureReference:6782018] RNA interference against transcription elongation factor SII does not support its role in transcription-coupled nucleotide excision repair [LiteratureReference:6782011] Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin [LiteratureReference:6782015] Cockayne syndrome group B protein enhances elongation by RNA polymerase II [LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template [LiteratureReference:6782041] Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells [LiteratureReference:5689269] Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin [LiteratureReference:6782184] ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair [LiteratureReference:9862017] Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair
modified	[InstanceEdit:6782052] Orlic-Milacic, Marija, 2015-06-03 [InstanceEdit:6782071] Orlic-Milacic, Marija, 2015-06-04 [InstanceEdit:6782178] Orlic-Milacic, Marija, 2015-06-05 [InstanceEdit:6782190] Orlic-Milacic, Marija, 2015-06-05 [InstanceEdit:6783709] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:6783799] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6792501] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792503] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:8865805] Matthews, Lisa, 2016-03-24 [InstanceEdit:8939807] Orlic-Milacic, Marija, 2016-09-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9862020] Orlic-Milacic, Marija, 2024-02-22 [InstanceEdit:9862097] Orlic-Milacic, Marija, 2024-02-22
name	Assembly of the pre-incision complex in TC-NER
output	[Complex:6782063] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II [Homo sapiens] [Reaction:6781833] ERCC8 (CSA) binds stalled RNA Pol II [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-03-06
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
reviewStatus	[ReviewStatus:9821385] four stars
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796921] R-HSA-6782004.5
structureModified	[InstanceEdit:9862020] Orlic-Milacic, Marija, 2024-02-22
summation	[Summation:6782051] In addition to ERCC6 (CSB) and the ERCC8 (CSA) ubiquitin lig...
(hasEvent)	[Pathway:6781823] Formation of TC-NER Pre-Incision Complex [Homo sapiens]
(precedingEvent)	[Reaction:6782069] UVSSA:USP7 deubiquitinates ERCC6 [Homo sapiens]
(replacementInstances)	[_Deleted:6793197] Deletion of instance: 109973
(updatedInstance)	[_UpdateTracker:9783314] Update Tracker - [Reaction:6782004] Assembly of the pre-incision complex in TC-NER - v57:[removeLiteratureReference] [_UpdateTracker:9864300] Update Tracker - [Reaction:6782004] Assembly of the pre-incision complex in TC-NER - v88:[add_removeLiteratureReference, modifyText, removeInput]
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