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Details on Person ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II

Class:Id	Reaction:6781867
_displayName	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
_doRelease	TRUE
_timestamp	2015-09-04 20:36:09
authored	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity	[CatalystActivity:6781858] ubiquitin protein ligase activity of Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6781857] Orlic-Milacic, Marija, 2015-06-03
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
input	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [Complex:6781839] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6781864] CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome [LiteratureReference:6781862] UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells [LiteratureReference:6782906] Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro
modified	[InstanceEdit:6781964] Orlic-Milacic, Marija, 2015-06-03 [InstanceEdit:6782912] Orlic-Milacic, Marija, 2015-06-09 [InstanceEdit:6783709] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:6783799] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6792501] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792503] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
output	[Complex:6781866] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6781833] ERCC8 (CSA) binds stalled RNA Pol II [Homo sapiens] [Reaction:6781840] ERCC6 binds stalled RNA Pol II [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796920] R-HSA-6781867.2
summation	[Summation:6781958] The ubiquitin ligase complex ERCC8:DDB1:CUL4:RBX1 may ubiqui...
(hasEvent)	[Pathway:6781823] Formation of TC-NER Pre-Incision Complex [Homo sapiens]
(precedingEvent)	[Reaction:6782004] Assembly of the pre-incision complex in TC-NER [Homo sapiens]
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No pathways have been reviewed or authored by ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (6781867)