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Details on Person USP19 is a deubiquitinating enzyme with a preference towards...
| Class:Id | Summation:6781768 |
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| _displayName | USP19 is a deubiquitinating enzyme with a preference towards... |
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| _timestamp | 2016-02-09 15:44:52 |
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| created | [InstanceEdit:6781793] Jupe, Steve, 2015-06-02 |
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| literatureReference | [LiteratureReference:6781809] Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
[LiteratureReference:6781773] USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1 |
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| modified | [InstanceEdit:6781817] Jupe, Steve, 2015-06-02
[InstanceEdit:6783058] Jupe, Steve, 2015-06-10
[InstanceEdit:8856270] Jupe, Steve, 2016-02-09 |
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| text | USP19 is a deubiquitinating enzyme with a preference towards Lys-63-linked ubiquitin chains (Iphofer et al. 2012). It deubiquitinates RNF123, preventing its proteasomal degradation which in turn stimulates CDKN1B ubiquitin-dependent degradation and thereby cell proliferation (Lu et al. 2009). |
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| (summation) | [Reaction:6781814] USP19 deubiquitinates RNF123 [Homo sapiens] |
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