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Details on Person UniProt:P07947 YES1
| Class:Id | ReferenceGeneProduct:67748 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-543 added on Sat February 7 2015;initiator methionine:1 for 67748 removed on Fri Nov 03 2023;initiator methionine: for 67748 added on Fri Nov 03 2023;initiator methionine: for 67748 removed on Fri Aug 15 2025;initiator methionine:1 for 67748 added on Fri Aug 15 2025 |
| _displayName | UniProt:P07947 YES1 |
| _timestamp | 2025-08-15 21:12:24 |
| chain | initiator methionine:1 chain:2-543 |
| checksum | A2B376084686BBCD |
| comment | FUNCTION Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622).CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG. Interacts with IL6ST/gp130 (PubMed:25731159). Interacts with SCRIB, when YES1 is in a closed conformation; the interaction facilitates YES1 autophosphorylation (PubMed:33730553).INTERACTION Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Localized to small puncta throughout the cytoplasm and cell membrane when in the presence of SNAIL1 (By similarity).TISSUE SPECIFICITY Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.PTM Phosphorylated (PubMed:11901164). Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.PTM Palmitoylation at Cys-3 promotes membrane localization.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. |
| description | recommendedName: Tyrosine-protein kinase Yes ecNumber: 2.7.10.2 alternativeName: Proto-oncogene c-Yes alternativeName: p61-Yes |
| geneName | YES1 YES |
| identifier | P07947 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell junction Cell membrane Cytoplasm Cytoskeleton Kinase Lipoprotein Membrane Myristate Nucleotide-binding Palmitate Phosphoprotein Proteomics identification Proto-oncogene Reference proteome SH2 domain SH3 domain Transferase Tyrosine-protein kinase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | YES1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989319] ENSEMBL:ENSG00000176105 YES1 [Homo sapiens] |
| secondaryIdentifier | YES_HUMAN A6NLB3 D3DUH1 |
| sequenceLength | 543 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:373640] YES1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1810411] MyrG-p-Y426-YES1 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:1810393] N-myristoylglycine at 2 [ModifiedResidue:1810400] O4'-phospho-L-tyrosine at 426 |
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No pathways have been reviewed or authored by UniProt:P07947 YES1 (67748)
