Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9Y3E5 PTRH2
| Class:Id | ReferenceGeneProduct:67730 |
|---|---|
| _chainChangeLog | transit peptide:1-62 added on Fri February 6 2015;chain:63-179 added on Fri February 6 2015;transit peptide:1-62 for 67730 removed on Fri August 11 2023;chain:63-179 for 67730 removed on Fri August 11 2023;chain:1-179 for 67730 added on Fri August 11 2023 |
| _displayName | UniProt:Q9Y3E5 PTRH2 |
| _timestamp | 2026-02-20 22:25:51 |
| chain | chain:1-179 |
| checksum | 11A0BA9ECF6B5E46 |
| comment | FUNCTION Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis (PubMed:14660562). Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.CATALYTIC ACTIVITY an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)SUBUNIT Monomer.SUBCELLULAR LOCATION Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the PTH2 family. |
| description | recommendedName: Peptidyl-tRNA hydrolase 2, mitochondrial shortName: PTH 2 ecNumber evidence="2"3.1.1.29 alternativeName: Bcl-2 inhibitor of transcription 1 |
| geneName | PTRH2 BIT1 PTH2 CGI-147 |
| identifier | Q9Y3E5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Apoptosis Disease variant Hydrolase Isopeptide bond Membrane Mitochondrion Mitochondrion outer membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | PTRH2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002571] ENSEMBL:ENSG00000141378 PTRH2 [Homo sapiens] |
| secondaryIdentifier | PTH2_HUMAN B3KUY4 Q9NTE5 |
| sequenceLength | 179 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5696909] PTRH2 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:6783190] PolyUb-PTRH2 [mitochondrial outer membrane] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:6783082] ubiquitinylated lysine (PolyUb [mitochondrial outer membrane]) at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y3E5 PTRH2 (67730)
