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Details on Person UniProt:O94892 ZNF432
| Class:Id | ReferenceGeneProduct:67660 |
|---|---|
| _chainChangeLog | chain:1-652 added on Sat February 7 2015 |
| _displayName | UniProt:O94892 ZNF432 |
| _timestamp | 2024-11-03 20:08:36 |
| chain | chain:1-652 |
| checksum | 14B61461EE54A6EB |
| comment | FUNCTION Homologous recombination repressor that functions as a poly(ADP-ribose) (PAR) reader regulating DNA damage response and PARP inhibition. Once recruited to DNA lesions via DNA-, in a PAR-dependent mechanism, stimulates PARP1 activity (PubMed:37823600). Binds preferentially ssDNA and inhibits EXO1-mediated resection, probably through a PAR-independent DNA-binding mechanism (PubMed:37823600).SUBUNIT Interacts with PARP1 and several chromatin remodeling proteins; the interaction with PARP1 reshapes ZNF432 interacting proteins (PubMed:37823600). Interacts with TRIM28; the interaction is independent of PARP1 (PubMed:37823600).INTERACTION Excluded from nucleolus (PubMed:37823600). Responds to DNA damage by relocating to damage sites, this relocation is PAR-dependent (PubMed:37823600).SIMILARITY Belongs to the krueppel C2H2-type zinc-finger protein family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Zinc finger protein 432 |
| geneName | ZNF432 KIAA0798 |
| identifier | O94892 |
| isSequenceChanged | FALSE |
| keyword | ADP-ribosylation DNA-binding Metal-binding Nitration Nucleus Proteomics identification Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ZNF432 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999872] ENSEMBL:ENSG00000256087 ZNF432 [Homo sapiens] |
| secondaryIdentifier | ZN432_HUMAN |
| sequenceLength | 652 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1247511] ZNF432 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O94892 ZNF432 (67660)
