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Details on Person UniProt:Q92611 EDEM1
| Class:Id | ReferenceGeneProduct:67540 |
|---|---|
| _chainChangeLog | chain:1-657 added on Sat February 7 2015 |
| _displayName | UniProt:Q92611 EDEM1 |
| _timestamp | 2024-11-03 19:56:01 |
| chain | chain:1-657 |
| checksum | E0097901B3BF02FB |
| comment | FUNCTION Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.SUBUNIT Interacts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L.SUBCELLULAR LOCATION Belongs to the glycosyl hydrolase 47 family. |
| description | recommendedName: ER degradation-enhancing alpha-mannosidase-like protein 1 |
| geneName | EDEM1 EDEM KIAA0212 |
| identifier | Q92611 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Endoplasmic reticulum Glycoprotein Membrane Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix Unfolded protein response |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | EDEM1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5642253] ENSEMBL:ENSG00000134109 EDEM1 [Homo sapiens] |
| secondaryIdentifier | EDEM1_HUMAN A8K9C8 B4DXP3 |
| sequenceLength | 657 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966056] UniProt:Q92611-1 EDEM1 [Homo sapiens] [ReferenceIsoform:8966057] UniProt:Q92611-2 EDEM1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:381083] EDEM1 [endoplasmic reticulum quality control compartment] [Homo sapiens] [EntityWithAccessionedSequence:1025953] EDEM1 [endoplasmic reticulum membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92611 EDEM1 (67540)
