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Details on Person UniProt:Q14691 GINS1
| Class:Id | ReferenceGeneProduct:67522 |
|---|---|
| _chainChangeLog | chain:1-196 added on Fri February 6 2015 |
| _displayName | UniProt:Q14691 GINS1 |
| _timestamp | 2024-11-03 19:42:56 |
| chain | chain:1-196 |
| checksum | 2270B5CE6C43BFE5 |
| comment | FUNCTION Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232).SUBUNIT Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4 (PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293). Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro (PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (PubMed:32453425, PubMed:34694004, PubMed:34700328).INTERACTION Associates with chromatin.INDUCTION Significantly up-regulated in aggressive melanomas.MASS SPECTROMETRY This is the measured mass for the GINS complex.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GINS1/PSF1 family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: DNA replication complex GINS protein PSF1 alternativeName: GINS complex subunit 1 |
| geneName | GINS1 KIAA0186 PSF1 |
| identifier | Q14691 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chromosome Disease variant DNA replication Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GINS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993842] ENSEMBL:ENSG00000101003 GINS1 [Homo sapiens] |
| secondaryIdentifier | PSF1_HUMAN Q9NQE2 Q9NQI7 |
| sequenceLength | 196 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:176955] GINS1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14691 GINS1 (67522)
