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Details on Person UniProt:Q14166 TTLL12
| Class:Id | ReferenceGeneProduct:67512 |
|---|---|
| _chainChangeLog | chain:1-644 added on Fri February 6 2015 |
| _displayName | UniProt:Q14166 TTLL12 |
| _timestamp | 2024-11-03 20:22:04 |
| chain | chain:1-644 |
| checksum | BFF552774DF500EF |
| comment | FUNCTION Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).SUBUNIT Interacts with MAVS; the interaction prevents MAVS binding to TBK1 and IKBKE (PubMed:28011935). Interacts (via N-terminus) with TBK1 (via protein kinase domain) (PubMed:28011935). Interacts (via TTL domain) with IKBKE (via protein kinase domain) (PubMed:28011935). Interacts with tubulin alpha (PubMed:23251473). Interacts with histone H3 and histone H4 (when trimethylated at 'Lys-20' (H4K20me3)) (PubMed:23251473). Interacts with CBX3 (PubMed:23251473).INTERACTION Predominantly localizes in the cytoplasm (PubMed:28011935). Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578).TISSUE SPECIFICITY Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions.SIMILARITY Belongs to the tubulin--tyrosine ligase family.CAUTION Although it belongs to the tubulin--tyrosine ligase family, the TTL domain lacks some of the ATP binding sites predicted to be essential for TTL activity (PubMed:23251473). Lacks tyrosine ligase activity in vitro (PubMed:23251473). Lacks glutamylation activity in vitro (By similarity). Although TTLL12 contains a potential SET-like domain in the N-terminus, it does not have lysine methyltransferase activity towards histone in vitro (PubMed:23251473). |
| description | recommendedName: Tubulin--tyrosine ligase-like protein 12 alternativeName: fullName evidence="8"Inactive tubulin--tyrosine ligase-like protein 12 |
| geneName | TTLL12 KIAA0153 |
| identifier | Q14166 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cytoplasm Cytoskeleton Immunity Innate immunity Nucleotide-binding Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TTLL12 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993971] ENSEMBL:ENSG00000100304 TTLL12 [Homo sapiens] |
| secondaryIdentifier | TTL12_HUMAN Q20WK5 Q9UGU3 |
| sequenceLength | 644 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8866300] TTLL12 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14166 TTLL12 (67512)
